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1. sso.uptodate.com › contents › dengue-virus-infectionDengue virus infection: Prevention and treatment - UpToDate

   sso.uptodate.com › contents › dengue-virus-infection

   Mar 7, 2024 · There are four dengue virus (DENV) types (DENV-1, DENV-2, DENV-3, and DENV-4), all of which are capable of inducing severe disease (dengue hemorrhagic fever [DHF]/dengue shock syndrome [DSS]).

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3. ncbi.nlm.nih.gov › pmc › articlesDengue: Update on Clinically Relevant Therapeutic Strategies ...

   ncbi.nlm.nih.gov › pmc › articles

   Apr 18, 2023 · Currently, the drugs are in phase 1 ( NCT05366439) and phase 2 ( NCT05466240) double-blind, randomized, placebo-controlled studies to assess the safety and antiviral activity in the dengue human challenge model and in dengue patients, respectively.

   • DOI: 10.1007/s40506-023-00263-w

   • Published: 2023

4. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 8, 2023 · The combinations of antivirals with different mechanisms of action could be evaluated to develop synergistic drug combinations for the treatment of dengue at any stage of the infection.

   • DOI: 10.3390/v15030705
   • Published: 2023/03

   • Publication: Viruses. 2023 Mar; 15(3): 705.

5. www.uptodate.com › contents › dengue-virus-infectionDengue virus infection: Clinical manifestations and diagnosis

   www.uptodate.com › contents › dengue-virus-infection

   • Cached

   Oct 5, 2022 · Dengue classification schemes support a range of activities from clinical triage and treatment to epidemiologic and vaccine and drug studies. Each guideline has been evaluated by a number of groups, and the 2009 classification has not superseded the 1997 classification for all aspects of DENV infection [ 12-16 ].

6. www.nejm.org › doi › fullDengue | New England Journal of Medicine

   www.nejm.org › doi › full

   Apr 12, 2012 · Dengue is caused by one of four single-stranded, positive-sense RNA viruses (dengue virus type 1 through dengue virus type 4), also referred to as serotypes) of the genus flavivirus (family...

7. pubmed.ncbi.nlm.nih.gov › 37124673Dengue: Update on Clinically Relevant Therapeutic Strategies ...

   pubmed.ncbi.nlm.nih.gov › 37124673

   There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies.

8. People also ask

   Can synergistic drug combinations be used for the treatment of dengue?

   • The combinations of antivirals with different mechanisms of action could be evaluated to develop synergistic drug combinations for the treatment of dengue at any stage of the infection.

   Molecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov/pmc/articles/PMC10056858/

   See all results for this question

   What type of virus causes dengue?

   • Dengue is caused by one of four single-stranded, positive-sense RNA viruses (dengue virus type 1 through dengue virus type 4), also referred to as serotypes) of the genus flavivirus (family Flaviviridae).

   Dengue | New England Journal of Medicine

   www.nejm.org/doi/full/10.1056/NEJMra1110265

   See all results for this question

   Are there new treatments for dengue?

   • There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies.

   Dengue: Update on Clinically Relevant Therapeutic Strategies and Vacci…

   ncbi.nlm.nih.gov/pmc/articles/PMC10111087/

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   What are the current treatment options for dengue-immune patients?

   • Current treatment options are limited and rely on supportive care. Although one dengue vaccine is approved for dengue-immune individuals and has modest efficacy, there is still a need for therapeutics and vaccines that can reduce dengue morbidities and lower the infection burden.

   Dengue: Update on Clinically Relevant Therapeutic Strategies ... - PubMed

   pubmed.ncbi.nlm.nih.gov/37124673/

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   Which clinical features are associated with severe dengue?

   • Clinical features observed to have a positive association with severe dengue include lethargy, persistent vomiting, abdominal pain, diarrhea, hepatomegaly, severe bleeding, pleural effusion, and ascites [ 29 ].

   Management of Dengue: An Updated Review - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9793358/

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   Is dengue a vector borne infection?

   • Dengue is a vector-borne infection caused by the dengue virus, a member of the Flaviviridae family. The virus is transmitted to humans by female mosquitoes of the species Aedes aegypti, less commonly Aedes albopictus, and a few other species. The dengue virus has 4 serotypes: DENV 1, 2, 3, and 4.

   Management of Dengue: An Updated Review - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC9793358/

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9. www.ncbi.nlm.nih.gov › pmc › articlesManagement of Dengue: An Updated Review - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 27, 2022 · The World Health Organization classifies dengue into probable dengue, dengue with warning signs, and severe dengue. Severe dengue, characterized by plasma leakage, severe bleeding, or organ impairment, entails significant morbidity and mortality if not treated timely.