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Oct 31, 2022 · It plays several roles in the pathogenicity of intestinal amoebiasis, including adherence to the host cell, cytotoxicity, complement resistance, induction of encystation, and generation of the cyst wall [24,25]. This protein contains a signal peptide and transmembrane domain; thus, it can be categorized as a membrane protein.
- 10.3390/membranes12111079
- 2022/11
- Membranes (Basel). 2022 Nov; 12(11): 1079.
May 21, 2021 · Another cytosolic protein, F-actin-capping protein subunit beta (EHI_005020), is a significant protein that has been detected because it takes roles in many functions including binding activities (molecular function); cellular process, biogenesis, and biological regulation (biological process); and cell/cell part (cellular component), which can ...
- Norhidayah Azmi, Nurulhasanah Othman
- 10.3390/membranes11060376
- 2021
- Membranes (Basel). 2021 Jun; 11(6): 376.
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- Historical Background
- Morphology and Biology
- Epidemiology
- Amebiasis in The Mediterranean Countries
- Pathophysiology
- Clinical Picture
- Ameboma
- Laboratory Diagnosis
- Microscopy
- Culture
Ronald Elsdon Dew made a full comprehensive description of the history of amoebae in a review article published in 1969 . He mentioned that Lösch was the first to report the amoebic trophozoites in the stools of a Russian patient in St. Petersburg suffering from severe dysentery in 1875. Definite association of amoeba with disease was established b...
Entamoeba histolytica occurs in the following forms, the trophozoites, precyst, cyst, metacyst, and metacystic trophozoite. The trophozoite is about 10–60 μm in size with a clear finely granular cytoplasm and a spherical nucleus that shows aggregation of chromatin beads at the nuclear membrane and a centrally located karyosome. The trophozoite is t...
Amebiasis is responsible for around 100,000 deaths/year, mainly in Central and South America, Africa, and India, as well as for a significant rate of morbidity manifested as invasive intestinal or extraintestinal disease . Infection with E. histolytica has been estimated to be as high as 50% in some developing countries as South and Central America...
The Mediterranean countries cover parts of the three old continents Africa, Asia, and Europe with an area of 2,085,292 km2 “(https://en.wikipedia.org/wiki/Mediterranean_Basin).” Its climate is generally moderate; however, it differs according to many factors as topography, plant cover, and rain fall. These differences plus political and financial s...
Amoebiasis is thought to be one of the most commonly known parasitic diseases affecting millions of people worldwide [57, 58]. Many of the cases have been discovered accidentally during a routine stool analysis and unfortunately many of them were given unneeded treatment for ameba. Those cases infected with the organism without symptoms were called...
Infection may be asymptomatic in most of the cases; however, severe fulminating disease may occur after an incubation period of 7–28 days from exposure to infection. Mild symptoms may be in the form of abdominal cramps, diarrhea with passage of 3–8 soft stools/day, or passage of stool with mucus and occasional blood. There may be fatigue, excessive...
It is one of the rare complications of colonic infection with pathogenic E. histolytica. It occurs as a result of deep invasion of the wall of the colon by invasive E. histolytica trophozoites with extensive formation of granulation tissue and the development of tumor-like mass. The most common sites of ameboma are the cecum and ascending colon. It...
Amebiasis is diagnosed in the laboratory by detecting the parasite in specimens or by an immunologic or a molecular technique [79,80,81,82,83]. In case of invasive intestinal amebiasis, the blood picture in 80% of cases may show leukocytosis without eosinophilia, elevation of erythrocytic sedimentation rate (ESR), elevation of serum alkaline phosph...
Identification of haematophagous trophozoites in fresh stool smears is the primary step for the identification of intestinal amebiasis and is an indication of infection [1•]. Because of irregular output of the parasite stages in stool, a single stool analysis is not usually positive. To further improve the sensitivity of the microscopic examination...
Culture is a method of diagnosis, however it is not easy to perform and less sensitive than microscopic examination with a success rate of 50–70% [1•]. Xenic cultivation, first introduced in 1925, is defined as the growth of the parasite in the presence of an undefined flora. This technique is still in use today utilizing the modified Locke egg or ...
- Nadia A. El-Dib
- naeldib@hotmail.com
- 2017
Entamoeba histolytica occurs in the following forms, the tro-phozoites,precyst,cyst,metacyst,andmetacystictrophozoite. The trophozoite is about 10–60 μm in size with a clear finely granular cytoplasm and a spherical nucleus that shows aggre-gation of chromatin beads at the nuclear membrane and a centrally located karyosome.
- Nadia A. El-Dib
- 2017
Ingested RBC; distinctive nucleus Cyst Stage: Chromatoidal body 'Cigar' shaped bodies (made up of crystalline ribosomes) Number of nuclei: 1 in early stages, 4 when mature Pathognomonic/diagnostic feature 'Ring and dot' nucleus and chromatoid bodies
Apr 1, 2022 · GTPases are molecular switches that regulate cellular processes such as cell polarity, gene transcription, microtubule dynamics, the cell cycle, cell migration, and vesicle trafficking [9,36]. A recent study by Verma et al. (2020) [ 37 ] characterized a Ca 2+ -binding protein from E. histolytica (EhCaBP6) as a novel GTPase.
Oct 31, 2022 · Entamoeba histolytica is a protozoan parasite that is the causative agent of amoebiasis. This parasite has caused widespread infection in India, Africa, Mexico, and Central and South America, and results in 100,000 deaths yearly. An immune response is a body's mechanism for eradicating and fighting against substances it sees as harmful or foreign. E. histolytica biological membranes are ...
