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Oct 9, 2012 · The mechanism of selenocysteine synthesis. Selenocysteine, also known as the 21st amino acid, is unique among the proteinogenic amino acids. It is the only amino acid containing an essential dietary micronutrient (selenium) as a constitutive component, the only amino acid encoded by a UGA codon and the only one synthesized on its tRNA in all domains of life.
- Figure 4
Mutations in components of the synthetic and decoding...
- Table 1
Selenocysteine, the 21st amino acid, has been found in 25...
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Point mutations in SepSecS give rise to progressive...
- The Selenocysteine-specific Elongation Factor Contains a Novel and Multi-functional Domain
The selenocysteine (Sec)-specific eukaryotic elongation...
- Secis
Background: Selenocysteine incorporation requires unique...
- PMC Free Article
Baron C, Böck A (1991) The length of the aminoacyl-acceptor...
- Structure of a tRNA-dependent Kinase Essential for Selenocysteine Decoding
Overall Structure. The crystal structure of MjPSTK was...
- Figure 4
Mar 21, 2024 · Proline is a non-essential amino acid and is coded by CCU, CCC, CCA, and CCG. It is the least flexible of the protein amino acids and thus gives conformational rigidity when present in a protein. Proline’s presence in a protein affects its secondary structure. It is a disrupter of α-helices and β-strands.
Selenocysteine (symbol Sec or U, [4] in older publications also as Se-Cys) [5] is the 21st proteinogenic amino acid. Selenoproteins contain selenocysteine residues. Selenocysteine is an analogue of the more common cysteine with selenium in place of the sulfur . Selenocysteine is present in several enzymes (for example glutathione peroxidases ...
Aug 1, 2013 · Abstract. Selenium is an essential trace element that is incorporated into 25 human proteins as the amino acid selenocysteine (Sec). The incorporation of this amino acid turns out to be a fascinating problem in molecular biology because Sec is encoded by a stop codon, UGA. Layered on top of the canonical translation elongation machinery is a ...
- Jonathan N. Gonzalez-Flores, Sumangala P. Shetty, Aditi Dubey, Paul R. Copeland
- 10.1515/bmc-2013-0007
- 2013
- 2013/08/08
Mar 10, 2011 · Mouse models that target removal or over-expression of the selenocysteine tRNA[Ser]Sec gene to elucidate the role of selenoproteins in health and development. : Hatfield DL, Berry MJ, Gladyshev VN, Selenium: its molecular biology and role in human health. New York: Springer; In press 2011 [Google Scholar]
- Anton A. Turanov, Xue-Ming Xu, Bradley A. Carlson, Min-Hyuk Yoo, Vadim N. Gladyshev, Dolph L. Hatfie...
- 10.3945/an.110.000265
- 2011
- Adv Nutr. 2011 Mar; 2(2): 122-128.
People also ask
How is selenocysteine encoded?
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How selenocysteine is encoded in selenoprotein mRNA?
How is selenocysteine synthesized and incorporated into a selenoprotein?
The complete set of correspondences between codons and amino acids (or stop signals) is known as the genetic code. _Image credit: " The genetic code ," by OpenStax College, Biology ( CC BY 3.0 )._. In the rest of this article, we'll more closely at the genetic code. First, we'll see how it was discovered.
thesis . A selenocysteine residue is encoded by the UGA codon in selenoprotein mRNA , which is decoded by selenocysteyl-tRNA [Ser]Sec [ 3 , 4 ]. The selenocysteine moiety on selenocysteyl-tRNA [Ser]Sec is biosynthesized using selenophosphate , which is produced from selenide and ATP by selenophosphate synthetase [ 5 , 6 ].
