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  1. Jan 22, 2021 · We found a random-effects estimate of 2824 neonatal sepsis cases per 100 000 live births (95% CI 1892 to 4194) in the overall time frame (before 1989–2018), with a 2.6 times higher incidence of EOS (2469/100 000, 95% CI 1424 to 4250) than LOS (946/100 000, 95% CI 544 to 1642) ( figure 3 ).

    • Figure 2

      Neonates are at major risk of sepsis, but data on neonatal...

  2. We found in 26 studies a pooled neonatal sepsis incidence of 2824 sepsis cases per 100 000 live births (95% CI 1892 to 4194) and a mortality of 17.6% (95% CI 10.3% to 28.6%). Preterm and very low birthweight neonates were particularly affected, and there were considerable regional differences in incidence.

    • Carolin Fleischmann, Felix Reichert, Alessandro Cassini, Rosa Horner, Thomas Harder, Robby Markwart,...
    • 2021
    • how has the epidemiology of neonatal sepsis changed over time statistics1
    • how has the epidemiology of neonatal sepsis changed over time statistics2
    • how has the epidemiology of neonatal sepsis changed over time statistics3
    • how has the epidemiology of neonatal sepsis changed over time statistics4
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  4. Oct 4, 2021 · Culture confirmed sepsis ocurred in three patients (0.3/1,000 live births), with the following agents: S. pneumoniae, S. epidermidis and S. agalactiae. As to site of infection, there were 35 cases of primary bloodstream infection, seven cases of pneumonia and four cases of meningitis.

    • Juliana Fernandes de Camargo, Jamil Pedro de Siqueira Caldas, Sérgio Tadeu Martins Marba
    • 2021
  5. Jan 18, 2020 · Among children younger than 5 years, the most common causes of sepsis in 2017 were diarrhoeal diseases (5·9 million [95% UI 2·1–14·2] cases of sepsis [27·9%, 95% UI 12·0–50·8]), neonatal disorders (5·1 million [2·9–8·9] cases of sepsis [25·7%, 13·7–40·9]), and lower respiratory infections (3·3 million [1·8–6·3] cases of ...

    • Global Level
    • Regional Level
    • National Level
    • Correlations of Asir and ASMR with SDI

    According to the present study, the incident cases of NS increased by 12.79% from 5.59 (95% UI 4.0–7.55) million in 1990 to 6.31 (95% UI 4.51–8.50) million in 2019, and the overall ASIR of NS increased by 14.35% (from 85.21 per 100,000 in 1990 to 97.43 per 100,000 in 2019). In the globe, the number of deaths of NS decreased by 12.93% (from 0.26 mil...

    For SDI regions, the percentage change in ASIR of NS increased in all five SDI regions from 1990 to 2019, with little increase in high-SDI regions (Fig. 1A, online supplemental Table 2). Among the five SDI regions, only low- and low-middle-SDI regions had an increase in incident cases (increased by 60.36% and 11.02%, respectively), whereas the rema...

    For 204 countries and territories, the absolute number of incident cases of NS was highest in China (1.11 million) in 2019, followed by India (0.75 million) (online supplemental Table 3). The largest increase of incident cases of NS was in North Macedonia (increased by 300.44%) from 1990 to 2019, followed by Afghanistan (increased by 241.37%) (Fig....

    During the period 1990–2019, correlations between SDI and ASIR/ASMR in NS were examined at the GBD regional level. The results showed that SDI was negatively correlated with ASIR (R = -0.3, P < 0.001) and ASMR (R = -0.76, P < 0.001) (online supplemental Fig. 1A, B). Global ASIR of NS showed an increasing level during 1990–2019 and had higher than e...

  6. Our estimates confirm that neonatal sepsis is an important contributor to neonatal morbidity worldwide, with a higher burden in LMICs. Based on the available evidence of 26 studies from 14 countries, we found an incidence of 2824 neonatal sepsis cases per 100 000 live births in the overall time frame.

  7. Jan 22, 2021 · Random-effects estimator for neonatal sepsis incidence in the overall time frame was 2824 (95% CI 1892 to 4194) cases per 100 000 live births, of which an estimated 17.6% 9 (95% CI 10.3% to...