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Apr 17, 2023 · Entamoeba histolytica is a protozoan that causes intestinal amebiasis as well as extra-intestinal manifestations. Although 90 percent of E. histolytica infections are asymptomatic, nearly 50 million people become symptomatic, with about 100,000 deaths yearly.
E. histolytica induces tissue damage by three main events: direct host cell death, inflammation, and parasite invasion. Once the trophozoites are excysted in the terminal ileum region, they colonize the large bowel, remaining on the surface of the mucus layer and feeding on bacteria and food particles.
Infection with Entamoeba histolytica (and E.dispar) occurs via ingestion of mature cysts from fecally contaminated food, water, or hands. Exposure to infectious cysts and trophozoites in fecal matter during sexual contact may also occur. Excystation occurs in the small intestine and trophozoites are released, which migrate to the large intestine.
Share. Abstract. Entamoeba histolytica is a protozoan parasite responsible for amoebiasis, a disease with a high prevalence in developing countries. Establishing an amoebic infection involves interplay between pathogenic factors for invasion and tissue damage, and immune responses for protecting the host.
- Eileen Uribe-Querol, Carlos Rosales
- 2020
Entamoeba histolytica represents one of the leading causes of parasitic death worldwide. Although identified as the causative agent of amebiasis since 1875, the molecular mechanisms by which the parasite causes disease are still not fully understood.
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Aug 19, 2019 · Entamoeba histolytica is a protozoan parasite of humans, and causative agent of amoebiasis. The parasite exists in two forms; an infective, non-dividing cyst stage and an actively dividing, invasive trophozoite. The dormant, non-motile cyst, upon ingestion by the host, gets converted to the actively dividing trophozoite in the colon.
