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10 723 nucleotides
- Both types of dengue fever, dengue hemorrhagic fever [ 1–8] and dengue shock syndrome, are deadly infections of five different serotypes of this virus (DENV 1–5) [ 9–14 ]. DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues.
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May 17, 2021 · For the purpose of computing the structural content of a complete genome (i.e., % double-stranded nucleotides), the total number of nucleotides with a score > 0 was averaged for the total length of each genome.
Sep 20, 2019 · These DENV can cause a spectrum of illness ranging from asymptomatic dengue infection to dengue fever (DF) to dengue hemorrhagic fever (DHF) to dengue shock syndrome (DSS). It is estimated that close to 3.6 billion are at risk with 390 million infections of which 96 million are symptomatic.
- Amudhan Murugesan, Mythreyee Manoharan
- 2020
- 10.1016/B978-0-12-819400-3.00016-8
The rate of nucleotide substitution for this virus has been estimated to be 6.5 × 10 −4 per nucleotide per year, a rate similar to other RNA viruses. The American African genotype has been estimated to have evolved between 1907 and 1949.
Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called serotypes because each has different interactions with the...
Sep 3, 2021 · 1. Introduction. Dengue fever, caused by the dengue virus (DENV), has been a major public health concern during the last few decades ( Bhatt et al. 2013 ). More importantly, it has been categorized as a “neglected tropical disease” ( Hotez et al. 2009 ).
Approximately 400 million cases and 22 000 deaths occur due to dengue worldwide each year. It has been reported in more than 100 countries in tropical and subtropical regions. A positive-stranded enveloped RNA virus (DENV) is principally transmitted by Aedes mosquitoes.
