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10 723 nucleotides
- Both types of dengue fever, dengue hemorrhagic fever [ 1–8] and dengue shock syndrome, are deadly infections of five different serotypes of this virus (DENV 1–5) [ 9–14 ]. DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues.
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Sep 20, 2019 · Dengue viruses (DENVs) form dengue complex in genus Flavivirus, family Flaviviridae, and consists of four antigenically related but distinct DENV serotypes (DENV-1, DENV-2, DENV-2, DENV-3, and DENV-4). These DENV can cause a spectrum of illness ranging from asymptomatic dengue infection to dengue fever (DF) to dengue hemorrhagic fever (DHF) to ...
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May 17, 2021 · For the next step, the structural content (mean of the % of double-stranded nucleotides for all the viral genomes) in a specific species was used to hierarchically group the 11 different viruses (Methods: Hierarchical clustering; Table Table1). 1).
- Riccardo Delli Ponti, Marek Mutwil
- 10.1186/s12864-021-07638-7
- 2021
- BMC Genomics. 2021; 22: 352.
Aug 30, 2013 · Nucleoside analogues are usually prodrugs that need to be converted to their antiviral nucleotide metabolite forms. Ribavirin (1-β-d-ribofuranosyl-1 H -1, 2, 4-triazole-3-carboxamide) possesses broad spectrum antiviral activity and is used in combination with IFN to combat HCV infection.
- Anne Tuiskunen Bäck, Åke Lundkvist
- 10.3402/iee.v3i0.19839
- 2013
- 2013
Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called serotypes because each has different interactions with the...
The rate of nucleotide substitution for this virus has been estimated to be 6.5 × 10 −4 per nucleotide per year, a rate similar to other RNA viruses. The American African genotype has been estimated to have evolved between 1907 and 1949.
- Structural Properties of The Denv Genomes
- Comparison of Structural Properties of The VHF Genomes
- Structural Content Can Be Used to Classify Vhfs
- Geographical Distribution of Denv Serotypes
Here, we analysed the secondary structure profiles of the complete genomes of more than 7000 ss-RNA viruses (Table 1; Methods: Source of viral genomes). The structural profiles were generated using the CROSS algorithm, a fast and comprehensive alternative to profile the structural content (i.e., % of double-stranded nucleotides) of long and complex...
Interestingly, DENV serotypes tend to be less structured than other flaviviruses, such as West Nile Fever virus (WNV), Yellow Fever virus (YFV), Tick-borne Encephalitis virus (TBV), and Japanese Encephalitis virus (JEV; Fig. 2). Even if not properly a VHF, we also used as comparison Zika virus (ZIKV), due to the similarities with DENV not only in t...
The overall similarities and differences in structure are an additional feature that could be employed to characterise the different viruses. For the next step, the structural content (mean of the % of double-stranded nucleotides for all the viral genomes) in a specific species was used to hierarchically group the 11 different viruses (Methods: Hie...
We also studied the geographical connection between DENV serotypes and the secondary structure content. We found that the African DENV-1 is predicted to be more structured than the other serotypes, even when compared with the Asian strains (Supplementary Figure 5 Kolmogorov-Smirnov = 0.001), while on the contrary, Asian DENV-3 is more structured th...
- Riccardo Delli Ponti, Marek Mutwil
- 2021
Sep 3, 2021 · Clinical symptoms of dengue range from mild fever to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS), with thrombocytopenia, leucopenia, and increased vascular permeability.
