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10 723 nucleotides
- Both types of dengue fever, dengue hemorrhagic fever [ 1–8] and dengue shock syndrome, are deadly infections of five different serotypes of this virus (DENV 1–5) [ 9–14 ]. DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues.
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Sep 30, 2021 · As the name suggests, structural proteins—Capsid (C), Envelope (E), pre-Membrane (prM)—are the structural component of a virus particle, involved in the encapsidation of viral RNA, i.e., nucleocapsid formation, membrane formation, maturation, and envelopment of the virion.
- Nikita Nanaware, Anwesha Banerjee, Satarupa Mullick Bagchi, Parikshit Bagchi, Anupam Mukherjee
- 10.3390/v13101967
- 2021
- Viruses. 2021 Oct; 13(10): 1967.
Nov 24, 2020 · This review article also gives a brief insight into the recent advances and research in dengue pathogenesis and the role of various biomarkers as early predictors of dengue disease severity. Go to: The four dengue virus serotypes (DENV1–4) have a 65–70% nucleotide sequence homology and are closely related [ 15 ].
- Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
- 10.1007/s00284-020-02284-w
- 2021
- Curr Microbiol. 2021; 78(1): 17-32.
May 17, 2021 · Dengue virus (DENV) is a mosquito-borne virus that can potentially infect more than 300 million people a year in more than 120 countries [ 1, 2 ]. DENV infection can further evolve into a severe hemorrhagic fever (severe dengue), which could lead to shock and death.
- Riccardo Delli Ponti, Marek Mutwil
- 10.1186/s12864-021-07638-7
- 2021
- BMC Genomics. 2021; 22: 352.
- Structural Properties of The Denv Genomes
- Comparison of Structural Properties of The VHF Genomes
- Structural Content Can Be Used to Classify Vhfs
- Geographical Distribution of Denv Serotypes
Here, we analysed the secondary structure profiles of the complete genomes of more than 7000 ss-RNA viruses (Table 1; Methods: Source of viral genomes). The structural profiles were generated using the CROSS algorithm, a fast and comprehensive alternative to profile the structural content (i.e., % of double-stranded nucleotides) of long and complex...
Interestingly, DENV serotypes tend to be less structured than other flaviviruses, such as West Nile Fever virus (WNV), Yellow Fever virus (YFV), Tick-borne Encephalitis virus (TBV), and Japanese Encephalitis virus (JEV; Fig. 2). Even if not properly a VHF, we also used as comparison Zika virus (ZIKV), due to the similarities with DENV not only in t...
The overall similarities and differences in structure are an additional feature that could be employed to characterise the different viruses. For the next step, the structural content (mean of the % of double-stranded nucleotides for all the viral genomes) in a specific species was used to hierarchically group the 11 different viruses (Methods: Hie...
We also studied the geographical connection between DENV serotypes and the secondary structure content. We found that the African DENV-1 is predicted to be more structured than the other serotypes, even when compared with the Asian strains (Supplementary Figure 5 Kolmogorov-Smirnov = 0.001), while on the contrary, Asian DENV-3 is more structured th...
- Riccardo Delli Ponti, Marek Mutwil
- 2021
Jan 10, 2017 · DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues. The polyprotein of DENV comprises three structural proteins (C, prM and E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) [ 15–19 ].
- Vivek Dhar Dwivedi, Indra Prasad Tripathi, Ramesh Chandra Tripathi, Shiv Kumar Bharadwaj, Sarad Kuma...
- 2017
Jun 11, 2015 · Within each of the four DENV serotypes, which share ~65–70 % amino acid sequence similarity [ 20 ], virus strains are further classified into distinct genotypes, which can vary by ~6–8 % at the nucleotide level and by 3 % at the amino acid level [ 21 – 24 ].
Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. These four viruses are called serotypes because each has different interactions with the...
