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1. • • The treatment plan is aimed at fluid rehydration continuation, overcoming infection and sepsis with antibiotics and source control; management of KAD with administration of fluids, insulin, and electrolyte correction.
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     Management of Sepsis Patient Aggravated by Diabetic Ketoacidosis

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   Does diabetes affect the outcome of sepsis?

   • Sepsis represents a rising cause of mortality worldwide and diabetes is a common and increasing comorbidity in septic patients. Although the higher risk of infection in diabetic patients is well documented, the impact of diabetes on the outcome of sepsis and the mechanisms underlying their interactions are still debated.

   Type 2 diabetes mellitus and sepsis: state of the art, certainties and miss…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC8316173/

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   Why do diabetic patients develop sepsis?

   • In this context, it is well established that the cells taking part in the innate and adaptive immune responses in diabetic patients have compromised function. These altered responses favor micro-organism growth, a process that contributes to sepsis progression.

   Diabetes Mellitus and Sepsis: A Challenging Association

   pubmed.ncbi.nlm.nih.gov/27787406/

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   How many patients with Type 2 diabetes develop sepsis?

   • A total of 502,871 patients with type 2 diabetes were recorded in the NDR between 1 January 2005 and 31 December 2015. Overall, 14,534 (2.9%) patients developed sepsis during the study period. Baseline characteristics of patients with sepsis and those without sepsis are summarized in Table 1 and Supplementary Table 2.

   Glycemic Control and Risk of Sepsis and Subsequent Mortality in Type 2

   diabetesjournals.org/care/article/45/1/127/139014/Glycemic-Control-and-Risk-of-Sepsis-and-Subsequent

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   How does H2R activation affect sepsis in diabetes mellitus (DM)?

   • H2R activation in diabetes mellitus (DM) aggravates sepsis by impairing neutrophil migration.DM causes an increase in the number of mast cells that degranulate after sepsis stimuli. Histamine release into the site of infection increases the level of blood histamine, which targets H2R on circulating neutrophils.

   Diabetes Mellitus and Sepsis: A Challenging Association : Shock - LWW

   journals.lww.com/shockjournal/Fulltext/2017/03000/Diabetes_Mellitus_and_Sepsis__A_Challenging.4.aspx

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3. www.ncbi.nlm.nih.gov › pmc › articlesType 2 diabetes mellitus and sepsis: state of the art,...

   www.ncbi.nlm.nih.gov › pmc › articles

   May 10, 2021 · This work aims at reviewing the current state of knowledge about: (1) the impact of diabetes and sepsis on the immune system, (2) the influence of diabetes on the risk of sepsis and its outcomes, and (3) the optimal target for blood glucose control during sepsis in patients with diabetes.

   • Table

     Lower overall ICU mortality (8.0% vs. 4.6%, p < 0.04) due to...

   • PMC

     The comorbidly challenged, physiologically frail diabetic...

4. www.ncbi.nlm.nih.gov › pmc › articlesDiabetes and Sepsis: Risk, Recurrence, and Ruination - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 30, 2017 · The comorbidly challenged, physiologically frail diabetic individuals suffer the highest infection rates. Recent reports suggest that even after clinical “recovery” from sepsis, persistent alterations in innate and adaptive immune responses exists resulting in chronic inflammation, immune suppression, and bacterial persistence.

   • Author: Lynn M. Frydrych, Fatemeh Fattahi, Katherine He, Peter A. Ward, Matthew J. Delano

   • Publish Year: 2017

5. journals.lww.com › shockjournal › FulltextDiabetes Mellitus and Sepsis: A Challenging Association - LWW

   journals.lww.com › shockjournal › Fulltext

   Jul 27, 2016 · H2R activation in diabetes mellitus (DM) aggravates sepsis by impairing neutrophil migration.DM causes an increase in the number of mast cells that degranulate after sepsis stimuli. Histamine release into the site of infection increases the level of blood histamine, which targets H2R on circulating neutrophils.

6. www.sepsis.org › 2021 › 03SEPSIS AND DIABETES - Sepsis Alliance

   www.sepsis.org › 2021 › 03

   SEPSIS INFORMATION GUIDE – SEPSIS AND DIABETES Diabetes is a chronic disease that has a significant impact on your life. Having diabetes means you must work to control your blood glucose (sugar) levels to be sure that they don’t get too high or too low. The amount of glucose in your blood is important. Your

7. pubmed.ncbi.nlm.nih.gov › 27787406Diabetes Mellitus and Sepsis: A Challenging Association

   pubmed.ncbi.nlm.nih.gov › 27787406

   In this context, it is well established that the cells taking part in the innate and adaptive immune responses in diabetic patients have compromised function. These altered responses favor micro-organism growth, a process that contributes to sepsis progression.

   • Author: Silvia Cellone Trevelin, Daniela Carlos, Matteo Beretta, Joao Santana da Silva, Fernando Queiroz Cun...

   • Publish Year: 2017

8. www.ncbi.nlm.nih.gov › pmc › articlesAssociation Between Diabetes Mellitus and Outcomes of ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jul 20, 2017 · The results from the meta-analysis suggest that DM does not impair the outcome of patients with sepsis, and the incidence of acute kidney injury increases dramatically in septic patients with DM. Due to the limitations of the analysis, more well-designed trials are still necessary.

9. diabetesjournals.org › care › articleGlycemic Control and Risk of Sepsis and Subsequent Mortality ...

   diabetesjournals.org › care › article

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   Dec 28, 2021 · OBJECTIVE. To investigate the nature of the relationship between HbA 1c and sepsis among individuals with type 2 diabetes, and to assess the association between sepsis and all-cause mortality in such patients. RESEARCH DESIGN AND METHODS.