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  1. Oct 12, 2021 · Overall, although preclinical studies suggest that KD has antitumor effects, prolongs survival, and prevents cancer development, human clinical trials are equivocal. Because of the lack of high-quality clinical trials, the effects of KD on cancer and as an adjunctive therapy are essentially unknown.

    • Table 1

      Pancreatic cancer Duodenal cancer Common bile duct cancer...

    • Figure 1

      Despite remarkable improvements in screening, diagnosis, and...

    • Overview
    • The keto diet slowed tumor growth, but had life-threatening risks
    • The keto diet may help some—but not all—cancer patients
    • The bottom line:

    •New research on the keto diet finds it may help to slow the growth of tumors, but may also be linked to a wasting syndrome.

    •The study was done on rodents and found that those with colorectal or pancreatic cancer on the keto diet were more likely to develop cachexia, a wasting syndrome that causes loss of skeletal muscle and fat

    •The findings suggest that while some people with cancer may benefit from the keto diet, in others, it may come with more risks than benefits.

    New research conducted in rodents has found that the ketogenic diet, also known as the keto diet, may help slow the growth of cancerous tumors.

    At the same time, the high-fat, low-carbohydrate diet could contribute to cachexia, a wasting syndrome that causes loss of skeletal muscle and fat, that may shorten survival.

    According to the report, published in Cell Metabolism on Monday, administering a steroid, like dexamethasone, alongside the keto diet may prevent the onset of cancer cachexia while continuing to slow tumor growth.

    The researchers evaluated the effects of a normal diet and low-carbohydrate, moderate-protein, high-fat ketogenic diet in mice with colorectal cancer and pancreatic cancer.

    They found that tumor growth was significantly delayed in the mice that were fed the keto diet, suggesting that the diet had a powerful anti-tumor effect.

    That said, the rodents on the keto diet were also more likely to develop cancer cachexia, losing large amounts of muscle mass and fat tissue, which shortened their survival compared to the mice with cancer who adhered to a normal diet.

    The researchers also found that the mice eating the keto diet were unable to produce enough corticosterone, a hormone that helps regulate the diet’s health effects. As a result, the mice continued to lose weight.

    “By eating keto (in mice), the cancer cells died faster, but the mice lost so much weight that they died earlier,” says Dana Ellis Hunnes, PhD, MPH, RD, a senior clinical dietitian at UCLA Medical Center, assistant professor at UCLA Fielding School of Public Health, and author of Recipe for Survival.

    The researchers then injected these mice with corticosteroids and found that the tumors continued to shrink but the mice didn’t develop cachexia.

    Previous research has shown that a low carbohydrate, or ketogenic diet, slows cancer growth.

    According to Hunnes, depending on the type of cancer, the cells will feed on glucose.

    “That’s their fuel of choice,” she said.

    When you deprive these cancer cells of glucose, they die off as they don’t have the fuel and energy they need to grow.

    That said, with certain cancers, the diet can accelerate the wasting disorder, cachexia.

    According to Perry, the likelihood of cachexia does not entirely negate the potential benefits of the keto diet in people with cancer.

    A new study suggests that the ketogenic diet may help slow the growth of cancerous tumors, however, it could also accelerate a wasting disorder called cachexia that may shorten survival. While the keto diet may be beneficial in some cancer patients, it may lead to a life-threatening amount of muscle and fat loss in others. More research is needed t...

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  3. Mar 2, 2020 · Finasteride can interfere with the estrogen/testosterone balance, leading to potential risk of estrogen-mediated malignant transformation; it should be avoided in those who have family history of breast cancer.23

    • Wimolsiri Iamsumang, Kanchana Leerunyakul, Poonkiat Suchonwanit
    • 10.2147/DDDT.S240615
    • 2020
    • Drug Des Devel Ther. 2020; 14: 951-959.
  4. April 18, 2018. The keto diet and cancer: What patients should know. BY Kellie Bramlet Blackburn. There’s no one food that can cure cancer, but that doesn’t stop such myths from circulating. And while researchers are starting to find some links between nutrition and cancer, more research is needed.

  5. Apr 3, 2021 · A ketogenic diet is acceptable in women with ovarian and endometrial cancer and has no adverse effects on blood lipids: a randomized. Control Trial Nutr Cancer. 2019 doi: 10.1080/01635581.2019.1645864.

    • Maximilian Römer, Jennifer Dörfler, Jutta Huebner
    • 10.1007/s10238-021-00710-2
    • 2021
    • Clin Exp Med. 2021; 21(4): 501-536.
  6. May 11, 2021 · Our pilot study at MSK is evaluating whether newly diagnosed endometrial cancer patients can tolerate a keto diet for three to four weeks before surgery. We are also evaluating whether the diet can help stabilize the body’s insulin and blood sugar levels and have positive effects at the actual tumor site.

  7. Overall, doses of oral finasteride ranged from 0.5 to 5 mg/day, in females aged 6-88, over a duration of 6-12 months (57.6%), as monotherapy (88.9%), and for continuous use (96.4%). Conclusion: The studies reviewed highlight the finasteride dosage, length of treatment, and candidate conditions that can benefit from finasteride therapy.

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