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Oct 14, 2021 · 1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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- 1959/09/22
- MONSANTO (J. FREEMAN)
- N-cyclohexylanilineN-cyclohexyl-N-phenylamine
- COBLENTZ NO. 08474
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Planning a Synthesis using a Reductive Amination. If you are trying to develop a synthesis of an amine molecule, the key bond break is a C-N bond in the target molecule. There may be multiple C-N bonds present, so each should be broken separately to produce a possible set of starting materials.
The compounds were prepared by several procedures. 1-( I-Pheiiylcyclohesyl)piperidine, the first compouiid of this type synthesized, was prepared from I-piperidinocyclohexanecarbonitrile by replacement of the cyano group by phenyl using phenylmagnesirim bromide.
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A series of phencyclidine homologs was synthesized by reductive cyclization of substituted ω-chlorine-substituted l-N- [l- (p-hydroxybenzyl)cyclohexyl]amides with LiAlH4 by characterized and tested for neurotropic activity. Expand. 1. Synthesis and biological activity of cyclohexylamine derivatives. V. A. Glushkov O. S. P’yankova. +4 authors.
An expedient synthesis of high specific activity tritium labelled 4‐fluoro‐1‐[1‐(2‐thienyl)]cyclohexylpiperidine ([ 3 H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex.
Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide -based reagents used as accelerators for vulcanization. It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators ).