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1. go.drugbank.com › drugs › DB015061-Phenylcyclohexylamine: Uses, Interactions, Mechanism of ...

   go.drugbank.com › drugs › DB01506

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   Jul 31, 2007 · Indication Contraindications & Blackbox Warnings Pharmacodynamics Mechanism of action Absorption Volume of distribution Protein binding Metabolism Route of elimination Half-life Clearance Adverse Effects Toxicity Pathways Pharmacogenomic Effects/ADRs

2. link.springer.com › referenceworkentry › 10Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

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   Jan 1, 2016 · The underlying mechanism of the emergence phenomena caused by arylcyclohexamines appears to be due to their depressive effects on visual and auditory relay nuclei in the medial geniculate and inferior colliculus, respectively, leading to misperception and/or misinterpretation of visual and auditory stimuli [287, 288].

3. People also ask

   What is phenylcyclohexyl piperidine (PCP)?

   • Phenylcyclohexyl piperidine (PCP), also known as phencyclidine, in tablet form. Image courtesy of the US Drug Enforcement Administration. Many drug users are unknowingly exposed to PCP because it is often used as an adulterant in marijuana, LSD, and methamphetamine to save on production costs of those other drugs.

   PCP and Ketamine Toxicity: Practice Essentials ... - Medscape

   emedicine.medscape.com/article/1010821-overview

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   Why do arylcyclohexamines cause misperception?

   • The underlying mechanism of the emergence phenomena caused by arylcyclohexamines appears to be due to their depressive effects on visual and auditory relay nuclei in the medial geniculate and inferior colliculus, respectively, leading to misperception and/or misinterpretation of visual and auditory stimuli [ 287, 288 ].

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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   How do arylcyclohexamines affect NMDA receptor antagonism?

   • The effects of NMDA receptor antagonism by arylcyclohexamines result in modulation of glutamatergic transmission [ 147 ]. Their primary effects, including anesthesia, analgesia, and psychotomimetic properties, relate to this action (see Pathophysiology, below).

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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   What are the main effects of arylcyclohexamines?

   • Chemical structures of the primary arylcyclohexamines: phencyclidine , ketamine , and methoxetamine The main effects of this class of agents are nystagmus, hypertension, and tachycardia in a behaviorally disturbed, and possibly violent, patient.

   Arylcyclohexamines (Ketamine, Phencyclidine, and Analogues)

   link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_124-1

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4. emedicine.medscape.com › article › 1010821-PCP and Ketamine Toxicity: Practice Essentials ... - Medscape

   emedicine.medscape.com › article › 1010821-

   Jan 30, 2022 · PCP is a noncompetitive antagonist at the glutamate NMDA receptor and binds to sites located in the cortex and limbic structures of the brain. This mechanism is believed to be responsible for most of the dissociative effects of PCP.

5. www.ncbi.nlm.nih.gov › books › NBK470357Ketamine - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK470357

   Jan 30, 2024 · Mechanism of Action. Ketamine hydrochloride is a nonbarbiturate dissociative anesthetic. As a cyclohexanone derivative, the drug rapidly acts and produces profound anesthesia and analgesia. Its chemical name is ±)-2-(o-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride; the structural formula is CHClNO.

   • Published: 2024/01/30

6. openstax.org › books › microbiology14.3 Mechanisms of Antibacterial Drugs - OpenStax

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   • Learning Objective. Describe the mechanisms of action associated with drugs that inhibit cell wall biosynthesis, protein synthesis, membrane function, nucleic acid synthesis, and metabolic pathways.
   • Inhibitors of Cell Wall Biosynthesis. Several different classes of antibacterials block steps in the biosynthesis of peptidoglycan, making cells more susceptible to osmotic lysis (Table 14.2).
   • Inhibitors of Protein Biosynthesis. The cytoplasmic ribosomes found in animal cells (80S) are structurally distinct from those found in bacterial cells (70S), making protein biosynthesis a good selective target for antibacterial drugs.
   • Inhibitors of Membrane Function. A small group of antibacterials target the bacterial membrane as their mode of action (Table 14.4). The polymyxins are natural polypeptide antibiotics that were first discovered in 1947 as products of Bacillus polymyxa; only polymyxin B and polymyxin E (colistin) have been used clinically.

7. webbook.nist.gov › cgi › cbookN-Phenylcyclohexylamine - NIST Chemistry WebBook

   webbook.nist.gov › cgi › cbook

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   Feb 6, 2010 · IUPAC Standard InChI: InChI=1S/C12H17N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2 Copy IUPAC Standard InChIKey: TXTHKGMZDDTZFD-UHFFFAOYSA-N ...

8. www.sciencedirect.com › topics › chemistryPhencyclidine - an overview | ScienceDirect Topics

   www.sciencedirect.com › topics › chemistry

   Toxicokinetics. Phencyclidine, or 1- (1-phenylcyclohexyl) piperidine, is synthesized from piperidine and cyclohexanone. It is a highly lipid-soluble solid that is soluble in both water and alcohol. It is a weak base with a pKa between 8.6 and 9.4. The dose of PCP varies depending on the amount of active drug and the route.

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