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      • In summary, the definition of RH has been modified from that of the 2008 AHA scientific statement in 4 important ways: (1) BP should be measured and the BP threshold for diagnosis and treatment goals should be in accord with current clinical practice guidelines 1; (2) patients should be taking ≥3 antihypertensive agents, commonly including a long-acting CCB, a blocker of the renin-angiotensin system (ACE inhibitor or ARB), and a diuretic at maximum or maximally tolerated doses; (3) patients with...
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  2. The diagnosis of RH requires assurance of antihypertensive medication adherence and exclusion of the “white-coat effect” (office BP above goal but out-of-office BP at or below target). The importance of RH is underscored by the associated risk of adverse outcomes compared with non-RH.

  3. Jun 13, 2018 · Resistant hypertension is almost always multifactorial in etiology. Successful treatment requires identification and reversal of lifestyle factors contributing to treatment resistance; diagnosis and appropriate treatment of secondary causes of hypertension; and use of effective multidrug regimens.

    • David A. Calhoun, Daniel Jones, Stephen Textor, David C. Goff, Timothy P. Murphy, Robert D. Toto, An...
    • 2008
  4. May 14, 2024 · Learn how to diagnose and manage resistant hypertension, a condition that requires more aggressive medication and specialized interventions. This article reviews the definition, epidemiology, risk factors, and evaluation of resistant hypertension, as well as secondary causes and their treatment.

  5. Feb 1, 2023 · In this article, we review the definition and prevalence of resistant hypertension and its diagnostic workup and management, including lifestyle modifications, drugs, and experimental interventional therapies.

  6. Jul 23, 2019 · In the 2017 AHA/ACC Hypertension Guidelines, resistant hypertension (RH) is defined as hypertension (HTN) that remains uncontrolled with three antihypertensives (including one diuretic), or blood pressure (BP) that is controlled on four medications. 1 The estimated prevalence of RH among treated hypertensives is approximately 13%. 2 RH is ...

  7. Aug 12, 2019 · The Eighth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 8) guidelines laid out more lenient target BP goals, without addressing the definition of resistant hypertension directly.

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