Search results
Os estreptomicetos[ 1] ( Streptomyces) são um grupo especial de bactérias filamentosas importante na decomposição de matéria orgânica. Incluí cerca de 500 espécies, que ocorrem no solo ou na água.
- Actinobacteria
- Actinobacteria
- Bacteria
- Actinomycetales
Estreptomicina. Estrutura química da estreptomicina. ( Código ATC: J01G A01 .) A estreptomicina foi o primeiro agente específico efetivo no tratamento da tuberculose. Foi também uns dos primeiros aminoglicosídeos descobertos. É um antibiótico bactericida de pequeno espectro. [ 1]
- Adult Dosing
- Pediatric Dosing
- Special Populations
- Contraindications / Cautions
- Adverse Reactions
- Pharmacology
Infections, Bacterial
1. 1-2 g/day IM divided q6-12h 1.1. Max: 2 g/day; Info: adjust dose based on serum levels 1.2. Renal dosing 1.2.1. Creatinine Clearance 50-80: give q24h 1.2.2. Creatinine Clearance 10-50: give q24-72h 1.2.3. Creatinine Clearance <10: give q72-96h
Active tuberculosis
1. 15mg/kg IM q24h 5-7x/wk 1.1. Alternative: 25-30mg/kg IM 2-3x/wk
1. 1g IM q12h x10 days 1.1. Maximum dose: 2 g/day (adjust dose based on serum levels)
Infections, Bacterial
1. 20-40mg/kg IM q24h 1.1. Alternative: 20-40mg/kg IM 2x/wk 1.2. Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk 1.3. Renal dosing 1.3.1. Creatinine Clearance 50-80: 7.5mg/kg give q24h 1.3.2. Creatinine Clearance 10-50: 7.5mg/kg give q24-72h 1.3.3. Creatinine Clearance <10: 7.5mg/kg give q72-96h
Active tuberculosis
1. 20-40mg/kg IM q24h 1.1. Alternative: 20-40mg/kg IM 2x/wk 1.2. Maximum dose: 1 g/dose if q24h, or 1.5 g/dose if 2x/wk
1. 15mg/kg IM q12h x10 days 1.1. Maximum dose: 2 g/day (adjust dose based on serum levels)
Lactation: Probably SafeMonitoring parameters:Contraindicated:caution if hypersensitivity to sulfitescaution if impaired vestibular functioncaution if impaired auditory functionSerious
1. Ototoxicity, auditory & vestibular 2. Neurotoxicity 3. Neuromuscular blockade 4. Nephrotoxicity 5. Anemia, hemolytic 6. Pancytopenia 7. Thrombocytopenia 8. Anaphylaxis 9. Angioedema 10. Hypersensitivity reaction 11. Exfoliative dermatitis 12. Superinfection
Common
1. Nausea and vomiting 2. Vertigo 3. Paresthesia, facial 4. Rash 5. Fever 6. Urticaria 7. Angioedema 8. Eosinophilia 9. Deafness 10. Exfoliative dermatitis 11. Anaphylaxis 12. Azotemia 13. Leukopenia 14. Thrombocytopenia 15. Pancytopenia 16. Anemia, hemolytic 17. muscle weakness 18. Amblyopia 19. Injection site reaction
Half-life: 5 hoursMetabolism: Unknown; CYP450Excretion: UrineMechanism of Action: Bactericidal (binds to 30S ribosomal subunit, inhibiting protein synthesis)São microrganismos aeróbicos, que se desenvolvem melhor em meios de cultura ricos em nutrientes. Em relação à morfologia, as Streptomyces são bactérias em forma de bastonete com ramificações filamentosas. Elas produzem esporos em cadeias que se assemelham a uma corrente de contas, o que lhes confere uma aparência distintiva sob o ...
Abstract. Streptomyces is a genus of Gram-positive bacteria that grows in various environments, and its shape resembles filamentous fungi. The morphological differentiation of Streptomyces involves the formation of a layer of hyphae that can differentiate into a chain of spores. The most interesting property of Streptomyces is the ability to ...
- Rudi Emerson de Lima Procópio, Ingrid Reis da Silva, Mayra Kassawara Martins, João Lúcio de Azevedo,...
- 2012
In veterinary medicine, streptomycin is the first-line antibiotic for use against gram negative bacteria in large animals ( horses, cattle, sheep, etc.). It is commonly combined with procaine penicillin for intramuscular injection. [medical citation needed] Tularemia infections have been treated mostly with streptomycin.
Jul 4, 2023 · Streptomycin is the first discovered aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria. This activity will discuss the indications, mechanism of action, and contraindications of using streptomycin ...
