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   Do patients with uveal melanoma develop metastases?

   • A large proportion of patients with uveal melanoma develop metastases and succumb to their disease. Reports on the size of this proportion vary considerably. PubMed, Web of Science and Embase were searched for articles published after 1980. Studies with ≥100 patients reporting ≥five-year relative survival rates were included.

   Long-term relative survival in uveal melanoma: a systematic ... - Nature

   www.nature.com/articles/s43856-022-00082-y

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   What is the prognosis of metastatic uveal melanoma?

   • Until January 2022, no systemic therapy had received regulatory approval for patients with metastatic uveal melanoma, and these patients have historically had a dismal prognosis owing to the limited efficacy of the available treatments.

   Advances in the clinical management of uveal melanoma

   www.nature.com/articles/s41571-022-00714-1

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   Are human uveal malignant melanoma metastases a challenge in ocular oncology?

   • Contrary to other cancers, treatment of human uveal malignant melanoma metastases has not evolved sufficiently remaining as a great challenge in the field of ocular oncology.

   Treatment of Metastatic Uveal Melanoma: Systematic Review

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7565536/

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2. www.webmd.com › melanoma-skin-cancer › expectationsMetastatic Uveal Melanoma: What to Expect - WebMD

   www.webmd.com › melanoma-skin-cancer › expectations

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   Mar 13, 2023 · Learn about metastatic uveal melanoma, a type of eye cancer that can spread to other parts of the body, especially the liver. Find out how it is diagnosed, staged, and treated, and what complications it may cause.

3. www.uptodate.com › contents › metastatic-uveal-melanomaMetastatic uveal melanoma - UpToDate

   www.uptodate.com › contents › metastatic-uveal-melanoma

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   Apr 3, 2024 · Timing of metastases — Most patients develop metastatic uveal melanoma within five to seven years of treatment to the primary eye tumor, with a median time of approximately three years . Metastases can also appear after a decade or longer [ 4-6 ].

4. www.ncbi.nlm.nih.gov › pmc › articlesMetastatic disease from uveal melanoma: treatment options and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Aug 29, 2016 · Uveal melanoma represents ∼85% of all ocular melanomas and up to 50% of patients develop metastatic disease. Metastases are most frequently localised to the liver and, as few patients are candidates for potentially curative surgery, this is associated with a poor prognosis.

   • Author: Richard D Carvajal, Gary K Schwartz, Tongalp Tezel, Brian Marr, Jasmine H Francis, Paul D Nathan
   • DOI: 10.1136/bjophthalmol-2016-309034

   • Publish Year: 2017
   • Publication: Br J Ophthalmol. 2017 Jan; 101(1): 38-44.

5. www.nature.com › articles › s41571/022/00714-1Advances in the clinical management of uveal melanoma - Nature

   www.nature.com › articles › s41571/022/00714-1

   Jan 4, 2023 · Advances in the metastatic setting are driving the development of novel adjuvant therapies that might reduce the risk of metastatic spread and increase cure rates for patients with uveal...

6. www.nature.com › articles › s43856/022/00082-yLong-term relative survival in uveal melanoma: a systematic ...

   www.nature.com › articles › s43856/022/00082-y

   Mar 1, 2022 · Abstract. Background. A large proportion of patients with uveal melanoma develop metastases and succumb to their disease. Reports on the size of this proportion vary considerably. Methods....

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8. www.ncbi.nlm.nih.gov › pmc › articlesTreatment of Metastatic Uveal Melanoma: Systematic Review

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 8, 2020 · Introduction: More than 50% of patients with uveal melanoma end up developing metastases. Currently, there is no standard first-line treatment that facilitates proper management of the metastatic disease.

9. www.uptodate.com › contents › management-ofManagement of metastatic uveal melanoma - UpToDate

   www.uptodate.com › contents › management-of

   Apr 20, 2021 · Uveal melanoma is a rare malignancy that arises from melanocytes within the uveal tract of the eye, which includes the iris, ciliary body, and choroid. Uveal melanoma comprises approximately 95 percent of melanomas arising from the eye, with the remainder arising mostly from the conjunctiva.