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  1. Aug 12, 2009 · The tetracycline antibiotic class has been used safely for long-term therapy in patients with rosacea and acne vulgaris. Within this antibiotic class, doxycycline is generally well tolerated. Minor side effects of tetracyclines are varied; serious side effects are rare. 56 (Table 3)

    • Sheila Valentín, Adisbeth Morales, Jorge L Sánchez, Abimael Rivera
    • 10.2147/ccid.s4296
    • 2009
    • 2009
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  3. Sep 13, 2024 · Immediate-release doxycycline (brand names include Vibramycin and Monodox), 100 to 200 mg per day, can be effective for rosacea. Doxycycline may also be prescribed at a lower dose of 20 mg twice a day with the brand-name drug Periostat. Modified-release doxycycline (Oracea) is administered at 40 mg once a day.

  4. Dec 2, 2021 · After 52 weeks of once‐daily treatment, subantibiotic dose doxycycline significantly reduced the relapse rate and inflammatory lesion counts in subjects with moderate‐to‐severe inflammatory rosacea. Keywords: metronidazole 1%, moderate or severe inflammatory lesions of rosacea, randomized controlled trial, remission, subantibiotic dose doxycycline.

    • 10.1111/dth.15180
    • 2022/01
    • Dermatol Ther. 2022 Jan; 35(1): e15180.
  5. May 11, 2023 · Oral doxycycline 40 mg, minocycline 100 mg, and minocycline 40 mg, as well as topical ivermectin and metronidazole 0.75%, were effective in treating papules and pustules, thereby decreasing IGA in rosacea. Among these, minocycline 100 mg ranked top in efficacy.

    • 10.3389/fphar.2023.1169916
    • 2023
    • Front Pharmacol. 2023; 14: 1169916.
  6. Apr 25, 2022 · Oral doxycycline at subantibiotic doses may be effective for the long-term management of rosacea, study data published in Dermatologic Therapy suggests. This 2-part study assessed the clinical effects of subantibiotic dose oral doxycycline 40 mg modified release (SDD 40) in patients with moderate to severe rosacea.

  7. Sep 29, 2023 · Researchers found that continued use of once-daily subantibiotic dose oral doxycycline 40 mg modified-release capsules significantly reduced the relapse rate and inflammatory lesion counts in patients with moderate-to-severe rosacea.

  8. Aug 12, 2009 · This study demonstrates that although both anti-inflammatory dose doxycycline (40 mg) and conventional dose doxycycline (100 mg) are effective once-daily treatments for moderate to severe rosacea, a higher incidence of adverse events is associated with the use of the 100 mg dose.

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