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Feb 25, 2020 · Overall, studies suggest that adherence rates for doxycycline range from 70% to 84% when it is used for malaria prophylaxis, and adhering to the dosing regimen may be more challenging than adhering to dosing regimens for weekly prophylaxis medications (e.g., mefloquine, tafenoquine).
- 2020/02/25
- Doxycycline overview
- Doxycycline side effects: Hyclate vs. monohydrate
- Doxycycline: More common side effects
- Doxycycline: Mild side effects
- Doxycycline: Serious side effects
- Doxycycline: Side effects in children
- Doxycycline: Side effect specifics
- Doxycycline: Long-term side effects
- Doxycycline: FAQs about side effects
- Doxycycline: Side effects after stopping treatment
Doxycycline is a generic prescription medication, and like other drugs, it can cause side effects. Doxycycline is used to help prevent malaria and treat certain bacterial infections such as:
•sexually transmitted infections
•respiratory infections
•severe acne and rosacea
•anthrax
Since doxycycline is typically used to treat infection, you’ll likely take the drug short term. In some cases, such as when doxycycline is used for acne or rosacea, you may take the drug for a longer period.
Doxycycline comes in two different versions: doxycycline hyclate and doxycycline monohydrate. Hyclate and monohydrate are the salt forms of the drugs. The purpose of a salt form is to help your body dissolve and absorb the drug better.
Both doxycycline hyclate and doxycycline monohydrate contain the same active drug: doxycycline. The two forms of doxycycline can be used to treat similar conditions and may cause similar side effects. The two drugs differ only in the type of salt used to make the drug. Both forms are currently considered equally effective.
Doxycycline can cause certain side effects (also known as adverse effects), some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.
These are just a few of the more common side effects reported by people who took doxycycline in clinical trials:
•decreased appetite
•diarrhea
•skin rash or hives
•nausea and vomiting*
Mild side effects can occur with doxycycline use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to doxycycline’s prescribing information.
Mild side effects that have been reported with doxycycline include:
•decreased appetite
•diarrhea
•skin rash or hives
•swelling of the tongue or digestive tract
Doxycycline may cause serious side effects. In most cases, serious side effects are rare.
The list below may not include all possible serious side effects of the drug. For more information, you can refer to doxycycline’s prescribing information.
If you develop serious side effects while taking doxycycline, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.
Serious side effects that have been reported and their symptoms include:
•Serious skin rash. Symptoms can include:
•peeling of the skin
If doxycycline is taken at certain points during pregnancy, the drug may cause tooth discoloration in the child. The discoloration can also occur in children younger than age 8 years who are given the drug. This side effect may be permanent, causing teeth to become yellow, gray, or brown in color.
Tooth discoloration is more common when the drug is taken for a long time. However, it can occur with a short treatment of doxycycline in children. In addition, less tooth enamel has been reported when the drug was given to children younger than age 8 years.
Due to these risks, doxycycline is not typically recommended for use in children younger than age 8 years. However, doctors may prescribe the drug for this age group in some cases. For example, doxycycline is the best treatment choice for anthrax in children.
If you have questions or concerns about side effects that doxycycline can cause in children, talk with your child’s doctor.
Nausea and vomiting
Nausea and vomiting are common side effects that people taking doxycycline reported in clinical trials.
Photosensitivity
It’s possible for doxycycline to cause photosensitivity, which may also be called sun sensitivity. This means that you can get a sunburn more easily than usual, and it may be more serious. Photosensitivity is a common side effect of doxycycline. Symptoms of photosensitivity reactions can include: •skin rash or blotchiness •blistering •itching or burning of the skin
Pericarditis
Although very rare, it’s possible for doxycycline to cause a heart-related side effect called pericarditis. This is swelling around your heart caused by an allergic reaction. This can cause symptoms such as: •chest pain •shortness of breath •cough •fatigue •heart palpitations
Most side effects that people experience with doxycycline are short term. This means that the side effects will likely go away after stopping treatment.
However, in rare cases, it’s possible to develop long-term side effects with doxycycline. Examples of these include:
•hemolytic anemia (a condition in which red blood cells are destroyed within blood vessels)
•decreased levels of white blood cells or platelets
•intracranial hypertension (high blood pressure in the head)
•pancreatitis (inflammation of the pancreas)
Should I expect side effects such as abdominal pain or an upset stomach with doxycycline?
Abdominal pain and upset stomach were not reported in clinical trials of people taking the drug. However, they can be symptoms of other side effects of doxycycline. For example, the drug may cause severe diarrhea or pancreatitis (inflammation of the pancreas). Either of these conditions may cause abdominal pain or upset stomach. If you experience pain in your abdomen or an upset stomach during your treatment with doxycycline, talk with your doctor. They can help determine the cause and how to treat your symptoms.
Does doxycycline cause headaches?
No, you shouldn’t experience headaches from taking doxycycline. This wasn’t a side effect that people taking doxycycline reported in clinical trials. It is possible for a headache to be a symptom of another doxycycline side effect. In rare cases, this drug can cause severe diarrhea (which may lead to dehydration) and increased pressure in your head. Dehydration and the increased pressure may cause a headache. If you experience headaches during doxycycline treatment, especially ones that are bothersome or severe, talk with your doctor. They can help determine the cause and recommend a treatment option.
Is constipation a possible side effect of doxycycline?
Constipation shouldn’t occur with doxycycline. Constipation wasn’t a side effect reported in clinical trials of people taking this drug. Instead, diarrhea was reported as a common side effect in people taking doxycycline. Your doctor can help with other concerns you may have about constipation.
You shouldn’t experience side effects after stopping treatment with doxycycline. Side effects weren’t reported after people stopped taking the drug in clinical trials.
However, if you’re taking doxycycline to treat acne or rosacea, it’s possible for the symptoms of your condition to return when you stop treatment. This is because the drug was working to treat these conditions, and you’re no longer taking it. For example, if you stop taking doxycycline for acne, your acne may flare up again.
Apr 23, 2024 · The most common doxycycline side effects include nausea and vomiting, upset stomach, loss of appetite, mild diarrhea, skin rash or itching, darkened skin color, and vaginal itching or discharge. Serious doxycycline side effects.
- Senior Editorial Pharmacist
- You should not take this medicine if you are allergic to doxycycline or other tetracycline antibiotics such as demeclocycline, minocycline, tetracy...
- Take doxycycline exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or sma...
- Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to...
- Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline.Avoid ta...
- Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may in...
May 1, 2024 · Vibramycin Calcium. Vibramycin Hyclate. Vibra-Tabs. Descriptions. Doxycycline is used to treat bacterial infections in many different parts of the body. It is also used to treat pimples and abscesses (usually on the face) that are caused by rosacea, also known as acne rosacea or adult acne.
The molecular formula for doxycycline hydrochloride hemiethanolate hemihydrate is (C 22 H 24 N 2 O 8 ∙HCl) 2 ∙C 2 H 6 O∙H 2 O and the molecular weight is 1025.89. Doxycycline is a light-yellow crystalline powder. Doxycycline hyclate is soluble in water, while doxycycline monohydrate is very slightly soluble in water.
The most commonly reported adverse events associated with the use of doxycycline are gastrointestinal symptoms and photosensitivity. Gastrointestinal symptoms are typically mild to moderate and include nausea (4–33%), abdominal pain (12–33%), vomiting (4–8%), and diarrhea (6–7.5%) ( Tan et al., 2011 ).
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