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  2. Dec 1, 2023 · Probably carcinogenic to humans. 95 agents. Group 2B. Possibly carcinogenic to humans. 323 agents. Group 3. Not classifiable as to its carcinogenicity to humans. 500 agents. For definitions of these groups, please see the Preamble.

  3. Group 2A: probably carcinogenic. Group 2B: possibly carcinogenic. Group 3: not classifiable. Group 4: probably not carcinogenic. IARC group 2B substances, mixtures and exposure circumstances are those that have been classified as "possibly carcinogenic to humans" by the International Agency for Research on Cancer (IARC) as [1] This category is ...

  4. Sometimes called the WHO “Encyclopedia of Carcinogens,” the IARC Monographs are critical reviews and evaluations of the weight of the evidence that an agent can increase the risk of cancer in humans.

    • Abstract
    • Motivation and Process For Preamble Revision
    • Key Changes in The Revised Preamble
    • Funding
    • Notes

    For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...

    Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...

    General Procedures

    The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...

    Scientific Review and Evaluation

    The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...

    This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.

    The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...

    • Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
    • 2020
  5. Feb 24, 2015 · The goal of the Monograph Programme is to assess carcinogenic hazards from occupational, environmental, and lifestyle exposures and agents, thus providing an essential step in the societal decision-making process to identify and then control carcinogenic hazards.

    • Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...
    • 2015
  6. Jun 16, 2023 · This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.

  7. Jan 23, 2024 · Human Cancer: Known Causes and Prevention by Organ Site. This poster presents the target organs for all agents classified as carcinogenic to humans (Group 1) by the IARC Monographs programme (in red text on the poster), and for the interventions showing sufficient evidence of a cancer-preventive effect in the IARC Handbooks of Cancer Prevention ...

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