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Oct 4, 2021 · Early neonatal sepsis (ENS) affects a significant number of newborns (NB), and is associated with increasing morbidity and mortality rates in the first week of life.
- Juliana Fernandes de Camargo, Jamil Pedro de Siqueira Caldas, Sérgio Tadeu Martins Marba
- 2021
Nov 1, 2022 · Neoreviews (2022) 23 (11): 756–770. Early-onset sepsis (EOS) is a significant cause of morbidity and mortality among newborn infants, particularly among those born premature. The epidemiology of EOS is changing over time.
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What predicts early detection of neonatal sepsis?
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Oct 1, 2020 · The most common early signs of sepsis in infants are fever or hypothermia, tachypnoea, lethargy, or new parental reports of poor feeding. Consider sepsis in infants with an apparent change in mental status, tone, or perfusion as well
- Principal Findings
- Predictors Assessed Compared with Other Studies
- Strengths
- Limitations
This systematic review illustrated that few articles were available on prediction modelling for fast detection of early/late/neonatal sepsis as whole. Out of those, most articles included had displayed satisfactory results in terms of prediction of the disease. Maternal, neonatal, clinical and laboratory predictors identified through these models w...
Included articles in our study had either utilised clinical/laboratory parameters, neonatal/maternal risk factors, or physiological events of the neonates for building the prediction model [22,23,24,25,26,27,28,29,30,31]. Birth weight characteristics, gestational age features, role of setting, sampling strategy and concomitant interventions were so...
Articles containing model validation part (internal/external) were particularly included in the review, as models without validation were of low robustness and accuracy and difficult to replicate in other settings [46,47,48].
Studies conducted in English language were only considered for the review due to which a number of articles had to be excluded and thus, can be considered as one of the shortcomings. Meanwhile, scarcity of data also affected the outcome of the review. Further research (both interventional and observational studies) is required in this field to gene...
Clinical Question. Can the neonatal early-onset sepsis calculator safely and accurately evaluate the risk of early-onset sepsis in neonates? Evidence Summary.
Jan 21, 2023 · Healthcare providers classify neonatal sepsis into two categories based on the age of onset: Early-onset neonatal sepsis: Most providers use the term “early-onset neonatal sepsis” to describe sepsis that develops within the first 72 hours of life.
Oct 11, 2017 · However, in clinical practice, serial measurements are more useful to monitor the patient’s response. CRP is quite unspecific and it does not differentiate sepsis from other diseases, but it is commonly used to screen for early onset neonatal sepsis (within the first 24 h of life) because its sensitivity has been shown to be very high .
