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Can a disease cause Ade?
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Mar 30, 2023 · Antibody-dependent enhancement (ADE) in dengue, a process mainly mediated by immunoglobulin G (IgG), is believed to be one of the major underlying mechanisms leading to increased severity in secondary DENV infection.
- Antibody‐dependent enhancement (ADE) of dengue virus ...
Antibody‐dependent enhancement (ADE) of dengue virus:...
- Intrinsic ADE: The Dark Side of Antibody Dependent ...
Intrinsic ADE has greater contribution in enhancing Dengue...
- Antibody‐dependent enhancement (ADE) of dengue virus ...
- What Is Ade?
- Is Ade Caused by A Disease?
- Is Ade Caused by Vaccines?
- Can The New Covid-19 Vaccines Cause Ade?
ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.
Most diseases do not cause ADE, but one of the best studied examples of a pathogen that can cause ADE is dengue virus. Dengue virus is one of the most common infections in the world, infecting hundreds of millions and killing tens of thousands of people each year. Unlike viruses like measles or mumps that only have one type, dengue virus has four d...
On a few occasions ADE has resulted from vaccination: 1. Respiratory syncytial virus (RSV) — RSV is a virus that commonly causes pneumonia in children. A vaccine was made by growing RSV, purifying it, and inactivating it with the chemical formaldehyde. In clinical trials, children who were given the vaccine were more likely to develop or die from p...
Neither COVID-19 disease nor the new COVID-19 vaccines have shown evidence of causing ADE. People infected with SARS-CoV-2, the virus that causes COVID-19, have not been likely to develop ADE upon repeat exposure. This is true of other coronaviruses as well. Likewise, studies of vaccines in the laboratory with animals or in the clinical trials in p...
The most widely known ADE example occurs with dengue virus. Dengue is a single-stranded positive-polarity RNA virus of the family Flaviviridae. It causes disease of varying severity in humans, from dengue fever (DF), which is usually self-limited, to dengue hemorrhagic fever and dengue shock syndrome, either of which may be life-threatening.
Antibody (Ab)-dependent enhancement of infection occurs when preexisting antibodies present in the body from a primary (first) dengue virus (DENV) infection...
Jan 24, 2019 · Dengue is a viral illness that is spread primarily by Aedes mosquitoes and infects ~390 million people each year worldwide 1. It is caused by dengue virus (DENV), which belongs to the family...
