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1. www.ncbi.nlm.nih.gov › pmc › articlesUnderstanding antibody-dependent enhancement in dengue: Are...

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 30, 2023 · Antibody-dependent enhancement (ADE) in dengue, a process mainly mediated by immunoglobulin G (IgG), is believed to be one of the major underlying mechanisms leading to increased severity in secondary DENV infection. ADE was shown to enhance viral entry into immune cells via their Fcγ receptors (FcγR), which promotes viral replication ...

   • Current Understanding of the Pathogenesis of Dengue Virus ...

     Dengue is a mosquito-borne Flavivirus infection, primarily...

   • Antibody‐dependent enhancement (ADE) of dengue virus ...

     Dengue virus (DENV) is an arbovirus transmitted mainly by...

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3. www.statnews.com › 2017/11/02 › dScientists solve a dengue mystery: Why second infection is ...

   www.statnews.com › 2017/11/02 › d

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   Nov 2, 2017 · Antibody-dependent enhancement, or ADE as it’s known in scientific circles, can happen, they reported, when subsequent infection occurs at a time when antibodies generated by the prior...

4. www.chop.edu › centers-programs › vaccine-educationAntibody-dependent Enhancement (ADE) and Vaccines

   www.chop.edu › centers-programs › vaccine-education

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   • What Is Ade?
   • Is Ade Caused by A Disease?
   • Is Ade Caused by Vaccines?
   • Can The New Covid-19 Vaccines Cause Ade?

   ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.

   See full list on chop.edu

   Most diseases do not cause ADE, but one of the best studied examples of a pathogen that can cause ADE is dengue virus. Dengue virus is one of the most common infections in the world, infecting hundreds of millions and killing tens of thousands of people each year. Unlike viruses like measles or mumps that only have one type, dengue virus has four d...

   See full list on chop.edu

   On a few occasions ADE has resulted from vaccination: 1. Respiratory syncytial virus (RSV) — RSV is a virus that commonly causes pneumonia in children. A vaccine was made by growing RSV, purifying it, and inactivating it with the chemical formaldehyde. In clinical trials, children who were given the vaccine were more likely to develop or die from p...

   See full list on chop.edu

   Neither COVID-19 disease nor the new COVID-19 vaccines have shown evidence of causing ADE. People infected with SARS-CoV-2, the virus that causes COVID-19, have not been likely to develop ADE upon repeat exposure. This is true of other coronaviruses as well. Likewise, studies of vaccines in the laboratory with animals or in the clinical trials in p...

   See full list on chop.edu

5. en.wikipedia.org › wiki › Antibody-dependent_enhancementAntibody-dependent enhancement - Wikipedia

   en.wikipedia.org › wiki › Antibody-dependent_enhancement

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   The suboptimal antibodies can result from natural infection or from vaccination. ADE may cause enhanced respiratory disease, but is not limited to respiratory disease. It has been observed in HIV, RSV virus and Dengue virus and is monitored for in vaccine development.

6. www.nature.com › scitable › contentModel of antibody-dependent enhancement of dengue infection

   www.nature.com › scitable › content

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   Antibody (Ab)-dependent enhancement of infection occurs when preexisting antibodies present in the body from a primary (first) dengue virus (DENV) infection bind...