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Which peptide has a reduced Ade effect on dengue virus (DENV)?
What is a direct-acting dengue therapeutic?
What is Ade & how does it work?
Mar 30, 2023 · Antibody-dependent enhancement (ADE) in dengue, a process mainly mediated by immunoglobulin G (IgG), is believed to be one of the major underlying mechanisms leading to increased severity in secondary DENV infection.
- Antibody‐dependent enhancement (ADE) of dengue virus ...
Antibody‐dependent enhancement (ADE) of dengue virus:...
- Antibody-Dependent Enhancement: A Challenge for Developing a ...
ADE is a phenomenon in which suboptimal neutralizing or...
- The Complexity of Antibody-Dependent Enhancement of Dengue ...
Abstract. Antibody-dependent enhancement (ADE) has been...
- Antibody‐dependent enhancement (ADE) of dengue virus ...
- What Is Ade?
- Is Ade Caused by A Disease?
- Is Ade Caused by Vaccines?
- Can The New Covid-19 Vaccines Cause Ade?
ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.
Most diseases do not cause ADE, but one of the best studied examples of a pathogen that can cause ADE is dengue virus. Dengue virus is one of the most common infections in the world, infecting hundreds of millions and killing tens of thousands of people each year. Unlike viruses like measles or mumps that only have one type, dengue virus has four d...
On a few occasions ADE has resulted from vaccination: 1. Respiratory syncytial virus (RSV) — RSV is a virus that commonly causes pneumonia in children. A vaccine was made by growing RSV, purifying it, and inactivating it with the chemical formaldehyde. In clinical trials, children who were given the vaccine were more likely to develop or die from p...
Neither COVID-19 disease nor the new COVID-19 vaccines have shown evidence of causing ADE. People infected with SARS-CoV-2, the virus that causes COVID-19, have not been likely to develop ADE upon repeat exposure. This is true of other coronaviruses as well. Likewise, studies of vaccines in the laboratory with animals or in the clinical trials in p...
Apr 18, 2023 · Tetravalent vaccine formulations developed with this aim are hindered by antigenic competition, wherein the immune response is skewed towards more immunodominant serotype-specific dengue antigens. Secondly, ADE poses a significant challenge in dengue vaccine development since vaccine-mediated sub-optimal protection to any of the dengue ...
The most widely known ADE example occurs with dengue virus. Dengue is a single-stranded positive-polarity RNA virus of the family Flaviviridae . It causes disease of varying severity in humans, from dengue fever (DF), which is usually self-limited, to dengue hemorrhagic fever and dengue shock syndrome, either of which may be life-threatening. [35]
