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  1. May 15, 2024 · Doxycycline is the first-line treatment for adults and children of all ages: Adults: 100 mg every 12 hours. Children under 45 kg (100 lbs): 2.2 mg/kg body weight given twice a day. Patients with suspected RMSF should be treated with doxycycline for at least 3 days after the fever subsides and there is evidence of clinical improvement.

  2. Treat early: RMSF can be rapidly fatal. Treatment is most effective if started within the first 5 days of symptoms. • Doxycycline is the treatment of choice in persons of all ages.* Early signs and symptoms: fever, headache, myalgia, fatigue (non-specific and can. mimic other illnesses).

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  4. RMSF is most often transmitted by the American dog tick in the Eastern, Central and Western United States; by the Rocky Mountain wood tick in the Rocky Mountain states; and by the brown dog tick in the Southwestern United States, along the U.S.-Mexico border. RMSF can be rapidly fatal if not treated within the first 5 days of symptoms.

  5. Rocky Mountain spotted fever (RMSF) is a potentially lethal, but usually curable, tick-borne disease. RMSF occurs throughout the United States, Canada, Mexico, Central America, and in parts of South America.

  6. Treatment. Rocky Mountain spotted fever is best treated by using a tetracycline antibiotic, usually doxycycline. Patients are treated for at least 3 days after the fever subsides and until there is evidence of clinical improvement. Standard duration of treatment is 5 to 10 days.

  7. Summary • Doxycycline is the drug of choice for treating RMSF in people of all ages. • • Empiric treatment with doxycycline is recommended in patients of all ages with suspected RMSF. Treatment is most effective at preventing death and severe RMSF when doxycycline is started within the first 5 days of symptoms.

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