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May 15, 2024 · A new vaccine for dengue received prequalification from the World Health Organization (WHO) on 10 May 2024. TAK-003 is the second dengue vaccine to be prequalified by WHO. Developed by Takeda, it is a live-attenuated vaccine containing weakened versions of the four serotypes of the virus that cause dengue.
Oct 30, 2023 · The potential risk for acquiring dengue virus in Los Angeles County and California remains low. Healthcare providers should consider dengue in any patient with a history of international travel and an acute febrile illness and other symptoms compatible with dengue.
5 days ago · Updated 6:43 AM PDT, June 26, 2024. NEW YORK (AP) — U.S. health officials on Tuesday warned doctors to be alert for dengue cases as the tropical disease breaks international records. The virus, which is spread by mosquitoes, has been surging worldwide, helped by climate change. In barely six months, countries in the Americas have already ...
5 days ago · Dr. James Shepherd, MD, an infectious diseases specialist at Yale Medicine, told Healthline that the dengue virus cannot mutate the way the COVID-19 virus has simply because there’s no cure for it.
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- Virus of many faces
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Dengue is on the march. This year, more than 4.2 million cases of the disease, which is caused by a virus transmitted by mosquitoes, had been reported by 2 October, compared with half a million in 2000. And the disease, which was once confined to the tropics, is spreading to new locations around the world, including southern Europe.
There is no specific treatment for dengue, which is also known as breakbone fever and can cause fever, bone pain and even death. The available vaccines have important limitations, and controlling the mosquitoes that transmit the disease is challenging.
But scientists are not sitting idle. At the annual meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), held in Chicago, Illinois, last month, researchers shared the latest results of their efforts to develop vaccines, antiviral medications and mosquito-control methods to curb the disease. Every available tool is needed, they say.
A key challenge for vaccine development is that dengue is caused by four distinct viral subtypes, or serotypes: DENV-1, DENV-2, DENV-3 and DENV-4. “The perfect dengue vaccine would have 90% efficacy across all different serotypes and would have the same level of efficacy for people who have had a previous dengue infection and those who have not,” says Timothy Endy, an immunologist also at SUNY Upstate Medical University. “We’re not there yet.”
Two dengue vaccines have received regulatory approvals so far. Dengvaxia, a vaccine made by Sanofi in Paris, has a 60% overall efficacy rate1 against symptomatic dengue, but it is only recommended for people who have had dengue before. This is because in those who have never been infected, the vaccine can actually exacerbate the risk of severe disease after infection through a mechanism called antibody-dependent enhancement.
6 days ago · There is a dengue vaccine for children aged 9 to sixteen if they have confirmation of a previous infection, or live in an area where dengue is common. Vaccines are recommended for U.S. territories ...
Feb 2, 2024 · Results of a phase 3 trial in the New England Journal of Medicine (NEJM) show 80% protection for the single-dose tetravalent (four-strain) Butantan-Dengue Vaccine (Butantan D-V) among participants with no evidence of previous dengue exposure and 89% protection in those with a history of exposure.
