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The eicosanoid pathways (via lipoxygenase or COX) add molecular oxygen (O 2). Although the fatty acid is symmetric, the resulting eicosanoids are chiral; the oxidations proceed with high stereoselectivity (enzymatic oxidations are considered practically stereospecific).
Sep 27, 2022 · Polyunsaturated fatty acids and their bioactive eicosanoids play a critical role in human health and diseases through regulating inflammation in the blood and the vessel. The role of the ω-6 PUFA AA in inflammation through formation of eicosanoids is well established.
- 10.3389/fphar.2022.997403
- 2022
- Front Pharmacol. 2022; 13: 997403.
Aug 3, 2023 · All eicosanoids with ring structures (example: prostaglandins and thromboxanes) are formed by the cyclooxygenase pathway. In this pathway, 2 isoforms of the cyclooxygenase enzyme, cyclooxygenase-1(COX-1), and cyclooxygenase-2 (COX-2) are involved.
This eicosanoid pathway consists of two main branches: ω-hydroxylases, which convert arachidonic acid to hydroxyeicosatetraenoic acids; and epoxygenases, which convert it to four regioisomeric epoxyeicosatrienoic acids (EETs; 5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET). 36 EETs regulate inflammation and vascular tone and are produced ...
- Bruce D Hammock, Weicang Wang, Molly M Gilligan, Dipak Panigrahy
- 10.1016/j.ajpath.2020.06.010
- 2020
- Am J Pathol. 2020 Sep; 190(9): 1782-1788.
Nov 18, 2020 · This article reviews the role of eicosanoids in cancer, with a focus on their role in modulating the tumor microenvironment. While the role of PGE2 will be discussed, data implicating other eicosanoids, especially products produced through the lipoxygenase and cytochrome P450 pathway will be examined.
- Amber M Johnson, Emily K Kleczko, Raphael A Nemenoff
- 10.3389/fphar.2020.595498
- 2020
- Front Pharmacol. 2020; 11: 595498.
Jul 3, 2015 · This study highlights the fact that a specific branch of the eicosanoid pathway — namely, prostaglandins produced by COX1 — is life-threatening when functioning systemically rather than acutely.
Aug 3, 2020 · This review examines the enzymology for the enzymes involved in the production of eicosanoids along the lipoxygenase branches of the eicosanoid pathways with particular emphasis on those derived from arachidonic acid.
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