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   How is megaloblastic anemia diagnosed?

   • West J Med. 1978 Apr; 128 (4): 294–304. The diagnostic approach to megaloblastic anemia involves four usually sequential steps. The first step, recognition of megaloblastosis, requires attention to altered blood cell size and morphology. These changes may sometimes be subtle or masked.

   The Laboratory Diagnosis of Megaloblastic Anemias - PMC

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   What is the MMA test for megaloblastic anemia?

   • Green R, Datta Mitra A. Megaloblastic anemias: nutritional and other causes. Med Clin North Am. 2017;101 (2):297-317. The MMA test is a sensitive and specific indicator of vitamin B 12 deficiency that can be used if the serum vitamin B 12 concentration is borderline. An elevated MMA concentration (>0.4 µmol/L) confirms vitamin B 12 deficiency.

   Megaloblastic Anemia | Choose the Right Test - ARUP Consult

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   What is megaloblastic and non-megaloblastic anemia?

   • It is divided into two forms, megaloblastic (hypersegmented neutrophils) and non-megaloblastic. The megaloblastic form is due to impaired DNA synthesis from folate and/or vitamin B12 deficiencies, while the non-megaloblastic moiety occurs from multiple mechanisms. Megaloblastic anemia occurs from deficiencies in folic acid and vitamin B12.

   Macrocytic Anemia - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK459295/

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2. www.uptodate.com › contents › diagnostic-approach-toDiagnostic approach to anemia in adults - UpToDate

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   A low hemoglobin concentration and/or low hematocrit are the parameters most widely used to diagnose anemia. The reference range depends on age and sex of the patient, as well as other factors such as altitude, prevalence of smoking in the normative population, and other factors ( table 1 ):

3. arupconsult.com › content › megaloblastic-anemiaMegaloblastic Anemia | Choose the Right Test - ARUP Consult

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   • Initial Evaluation
   • Evaluation For Vitamin Deficiency
   • Evaluation For Pernicious Anemia

   For information on the initial evaluation of anemia, see the ARUP Consult Anemiatopic. Testing for megaloblastic anemia is often prompted by the identification of macrocytosis from a CBC; if neurologic symptoms or other clinical features prompt testing, a CBC should be performed. Hemoglobin and hematocrit can be measured to confirm anemia. Once mac...

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   Vitamin B12 and/or folate deficiency may result in megaloblastic anemia. Because vitamin B12 deficiency is much more common than folate deficiency, the evaluation should commence with tests for vitamin B12, or a combined vitamin B12/folate test can be used.

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   The majority of patients with pernicious anemia have antibodies for parietal cells and IF.3Kjeldsberg, CR, ed. Practical Diagnosis of Hematologic Disorders. 5th ed. American Society for Clinical Pathology; 2010. In patients with confirmed vitamin B12 deficiency, testing for pernicious anemia is recommended. In patients with borderline vitamin B12an...

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4. www.ncbi.nlm.nih.gov › books › NBK459295Macrocytic Anemia - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK459295

   Jul 11, 2022 · Megaloblastic anemia occurs from deficiencies in folic acid and vitamin B12. Folate deficiency is due to diminished intake (alcohol abuse or malnutrition), increased consumption (hemolysis or pregnancy), malabsorption (familial, gastric bypass, or medications like cholestyramine or metformin).

   • Author: Christine A. Moore, Abdullah Adil

   • Published: 2022/07/11

5. emedicine.medscape.com › article › 204066-overvieMegaloblastic Anemia: Practice Essentials, Pathophysiology ...

   emedicine.medscape.com › article › 204066-overvie

   Jun 27, 2017 · See 21 Hidden Clues to Diagnosing Nutritional Deficiencies, a Critical Images slideshow, to help identify clues to conditions associated with malnutrition. The objectives of this article are to...

6. emedicine.medscape.com › article › 204066-workupMegaloblastic Anemia Workup - Medscape

   emedicine.medscape.com › article › 204066-workup

   Jun 27, 2017 · Megaloblastic Anemia Workup. Updated: Jun 27, 2023. Author: Srikanth Nagalla, MD, MS, FACP; Chief Editor: Emmanuel C Besa, MD more... Print. Approach Considerations. The anemia should be...

7. www.msdmanuals.com › en-gb › professionalMegaloblastic Macrocytic Anemias - Hematology and Oncology ...

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   Pathophysiology |. Symptoms and Signs |. Diagnosis |. Treatment |. Key Points. Megaloblastic anemias result most often from deficiencies of vitamin B12 and folate. Ineffective hematopoiesis affects all cell lines but particularly red blood cells.

8. www.ncbi.nlm.nih.gov › pmc › articlesThe Laboratory Diagnosis of Megaloblastic Anemias - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 4, 2016 · Abstract. The diagnostic approach to megaloblastic anemia involves four usually sequential steps. The first step, recognition of megaloblastosis, requires attention to altered blood cell size and morphology. These changes may sometimes be subtle or masked. The cornerstone of the second step, identification of the specific vitamin deficiency, is ...