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Feb 6, 2010 · Formula: C 12 H 17 N. Molecular weight: 175.2701. IUPAC Standard InChI: InChI=1S/C12H17N/c1-3-7-11 (8-4-1)13-12-9-5-2-6-10-12/h1,3-4,7-8,12-13H,2,5-6,9-10H2. IUPAC Standard InChIKey: TXTHKGMZDDTZFD-UHFFFAOYSA-N. CAS Registry Number: 1821-36-9. Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file.
Phencyclidine (PCP) is believed to be the first arylcyclohexylamine with recognized anesthetic properties, but several arylcyclohexylamines were described before PCP in the scientific literature, beginning with PCA (1-phenylcyclohexan-1-amine) the synthesis of which was first published in 1907.
CompoundAryl SubstituentN GroupCyclohexyl Ring2-HO-PCPPhenylPiperidine2-Hydroxy2-Me-PCPPhenylPiperidine2-Methyl2-MeO-PCPPhenylPiperidine2-Methoxy2-Keto-PCPPhenylPiperidine2-KetoPeople also ask
Which arylcyclohexylamine was first synthesised?
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Apr 2, 2013 · Preparation and analytical characterization of 1‐ (1‐phenylcyclohexyl)piperidine (PCP) and 1‐ (1‐phenylcyclohexyl)pyrrolidine (PCPy) analogues - Wallach - 2014 - Drug Testing and Analysis - Wiley Online Library.
- Jason Wallach, Giorgia De Paoli, Adeboye Adejare, Simon D. Brandt
- 2014
Jan 1, 2016 · The first arylcyclohexamine to be described was 1-(1-phenylcyclohexyl) amine, in 1907, almost 50 years before the synthesis of PCP . Other analogues reported in the early 1950s included N -ethyl-1-phenylcyclohexylamine (PCE) and 1-(1-phenylcyclohexyl)morpholine (PCMo).
The Synthesis of Phencyclidine and Other 1--4rylcyclohexylamines Received Juniiary 10, 1964 Revised Manuscripi Received October 2 $, 1!64 \-arious 1-arylcyclohesylaniiiies were synthesized fur evaliiatioii :ti ceiitral nervous system depressants. The compounds were prepared by several procedures.
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Mar 1, 2019 · Anilines and cyclohexylamines are currently produced from fossil feedstocks. Phenol would be an attractive alternative feedstock that can be obtained from renewable resources. We herein clarify the influence of the amine on the course of the amination of phenol using a hydrogen borrowing strategy.
Sep 7, 2023 · Introduction. [1-Phenylcyclohexyl]piperidine (Phencyclidine, PCP, I) is a noncompetitive antagonist of the NMDA (N-methyl-Daspartate) subcategory of the glutamate receptor that leads to the release and decrease of reabsorbing of monoaminergic neurotransmitters such as dopamine, serotonin, and norepinephrine [ 1 ].
