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  1. Oct 29, 2022 · Prescription weight-loss drugs that you can use for more than 12 weeks, called long-term use, lead to major weight loss compared with an inactive treatment that doesn't use medicine, called a placebo.

    • Oral semaglutide. What it is: Oral semaglutide is a glucagon-like peptide-1 (GLP-1) agonist. It mimics the effects of GLP-1, a gut hormone that's involved in blood glucose (sugar) control, digestion, and appetite management.
    • Orforglipron. What it is: Orforglipron is an oral GLP-1 agonist. Unlike injectable GLP-1 agonists, it’s made of chemicals — not peptides (amino acid chains).
    • Danuglipron. What it is: Danuglipron is an oral GLP-1 pill. It works the same way as orforglipron. How it’s administered: Danuglipron is an oral tablet.
    • APH-012. What it is: APH-012 is an oral medicine that imitates the metabolic effects of gastric bypass (weight loss) surgery. It’s a glucose pill that’s designed to stimulate certain parts of your small intestine.
  2. Mar 21, 2023 · Ozempic, Wegovy, and Mounjaro are all drugs that can be used to treat type 2 diabetes. But you’ve likely heard of them because they’re all over the news lately—especially for the controversy surrounding their use for weight loss among celebrities.

  3. Feb 15, 2024 · This article will discuss eight current Food and Drug Administration (FDA)–approved weight loss drugs on the market.

  4. The table below lists prescription drugs approved by the FDA for weight loss. The FDA has approved five of these drugsorlistat (Xenical, Alli), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), liraglutide (Saxenda), and semaglutide (Wegovy)—for long-term use.

    • healthinfo@niddk.nih.gov
  5. Apr 1, 2024 · Some popular weight-loss pills are Contrave (naltrexone / bupropion), Qsymia (phentermine / topiramate ER), and phentermine (Adipex-P). Some clinical studies suggest that Qsymia is the most effective weight loss pill. However, it’s a controlled substance that may not be the best option for everyone.

  6. Mar 25, 2024 · Prescription weight loss drugs may be an option for adults or children who have serious health risks, such as high blood pressure, type 2 diabetes, or high cholesterol and cannot control their weight with diet and exercise alone.

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