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Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. However, they are not omnipresent; for example, they have not been found in Escherichia coli.
Abstract. Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions.
Cytochrome P450 enzymes play roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin ...
Apr 24, 2023 · The role of cytochrome P450 (CYP) has been vastly studied for years regarding its influence in drug therapy. Predominantly operating within hepatocytes, their principal function is to metabolize hosts of xenobiotics and clearance of potentially toxic compounds.
Feb 2, 2018 · The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily, members of which catalyze the oxidative transformation of a wide range of organic substrates, and whose functions are crucial to xenobiotic metabolism and steroid transformation in humans and other organisms.
Nov 26, 2021 · Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis.
Editors: Paul R. Ortiz de Montellano. Two-volume Fourth Edition updated with the most cutting-edge research. Explores the advances of the past decade on the structure, mechanism, and biochemistry of cytochrome P450 enzymes. Discusses structure and role of cytochrome P450 in biology.
Cytochrome P450, or CYP genes, constitute one of the largest family of genes, with representatives in virtually all living organisms, from bacteria to protists, plants, fungi, and animals ( Werck-Reichhart and Feyereisen, 2000 ).
Feb 26, 2019 · The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components.
Nov 8, 2022 · This article provides a summary of cytochrome P450 enzyme inducers and inhibitors as well as the relevance of genetic polymorphisms which influence metabolic pathways.
