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IntAct is a database of experimentally determined molecular interactions, curated by experts and updated daily. It allows users to search, browse, download and explore interactions using various features and formats.
Jan 1, 2022 · The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange ...
- 10.1093/nar/gkab1006
- 2022/01/01
- Introduction
- Database Structure and Access
- Implementation
- Discussion
- Acknowledgements
Protein interactions provide a valuable resource for the elucidation of cellular function, and protein interaction studies have been a focus of recent biomolecular research. Experimental technologies like two‐hybrid systems ( 1 ) or tandem affinity purification ( 2) allow the generation of large quantities of interaction data. However, practically ...
Data model
The IntAct data model has three main components: Experiment, Interaction and Interactor. An Experiment groups a number of Interactions, usually from one publication, and classifies the experimental conditions in which these Interactions have been generated. An Experiment may have only a single interaction, or hundreds of interactions in the case of large‐scale experiments. An Interactor is a biological entity participating in an Interaction, usually a protein, but potentially also a DNA seque...
Controlled vocabularies
A curated protein interaction database integrates data from many sources, and a major database maintenance task is to ensure data consistency. Data attributes, e.g. experimental methods, must be annotated in a consistent manner to ensure the data remain correct and searchable. Naming variations like ‘yeast two hybrid’ and ‘Y2H’ are easy to understand for a scientist, but they are very difficult to search for in a consistent manner. In addition, it is often desirable to group data according to...
Database access
IntAct currently provides a simple search interface that searches the database by name, by IntAct accession number, or by identifiers of external databases, for example GO, Swiss‐Prot ( 6 ) and SGD ( 7). The data retrieved can be displayed in two views, a binary view (Fig. 1 ) and an experiment view (Fig. 2 ). For a given protein, the binary view displays all its known interaction partners and their minimal textual description. This may quickly give indications of potential functional roles f...
IntAct is Java based, and all required internal and external components are publicly available. Using the OJB ( http://db.apache.org/ojb/ ) object‐relational mapping tool, IntAct can access either Oracle ( http://www.oracle.com/ ) or Postgres ( http://www.postgresql.org/ ) relational database systems. Based on the database access layer, the IntAct ...
Storage, retrieval and visualization of protein interaction data is provided by several publicly available databases, in particular BIND ( 10 ), DIP ( 11 ), MINT ( 12 ), CYGD ( 13 ) and STRING ( 14 ). While the data models and some of the features of these databases have influenced IntAct, additional features such as the representation of binary an...
IntAct is funded by EU grant number QLRI‐CT‐2001‐00015 under the RTD programme ‘Quality of Life and Management of Living Resources’.
- Henning Hermjakob, Luisa Montecchi-Palazzi, Chris Lewington, Sugath Mudali, Samuel Kerrien, Sandra E...
- 2004
Jan 1, 2004 · IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins.
Jan 1, 2004 · IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins.
