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Jun 1, 2022 · Learn about the therapeutic use and toxicity of high-dose methotrexate (HDMTX) for various malignancies, and how leucovorin is used to reverse its effects. Find out the definition, dosing, and management of HDMTX-related complications.
Jul 3, 2023 · Leucovorin is a medication used in the treatment of methotrexate toxicity and chemotherapy regimens. Leucovorin is a folate analog. This activity reviews the indications, action, and contraindications for leucovorin as a valuable agent in the reversal of methotrexate toxicity and as a part of chemotherapy regimens. This activity will highlight the mechanism of action, adverse event profile ...
- Vishwajit S. Hegde, Shivaraj Nagalli
- 2023/07/03
- Yuma Regional Medical Center
- Usual Adult Dose For Colorectal Cancer
- Usual Adult Dose For Methotrexate Rescue
- Usual Adult Dose For Megaloblastic Anemia
- Usual Adult Dose For Folic Acid Antagonist Overdose
- Usual Adult Dose For Pneumocystis Pneumonia
- Usual Adult Dose For Pneumocystis Pneumonia Prophylaxis
- Usual Adult Dose For Toxoplasmosis
- Usual Pediatric Dose For Methotrexate Rescue
- Dose Adjustments
- Other Comments
- GeneratedCaptionsTabForHeroSec
200 mg/m2, by slow IV injection (minimum 3 minutes), followed by 5-fluorouracil (the manufacturer product information should be consulted), once a day for 5 days OR 20 mg/m2, IV, followed by 5-fluorouracil (the manufacturer product information should be consulted), once a day for 5 days Comments: 1. Do not be mix in the same infusion as 5-fluoroura...
Leucovorin Rescue: 15 mg (approximately 10 mg/m2), orally, IV, or IM, every 6 hours for 10 doses; start 24 hours after beginning of methotrexate infusion (based on a methotrexate dose of 12 to 15 g/m2 IV over 4 hours) Impaired Methotrexate Elimination or Inadvertent Overdosage: 10 mg/m2 orally, IV, or IM, every 6 hours until methotrexate level is l...
Up to 1 mg, IV or IM, once a day Comments: 1. There is no evidence that doses above 1 mg daily have greater efficacy; additionally, urinary folate loss becomes roughly logarithmic as the amount administered exceeds 1 mg.
5 to 15 mg orally once a day Use:Diminish the toxicity and counteract the effects of inadvertent overdosages of folic acid antagonists.
Treatment of pneumocystis pneumonia is not is not a labeled indication. 20 mg/m2 or 0.5 mg/kg, IV or orally, every 6 hours, continued for 3 days after last trimetrexate dose Comments: 1. Use in combination with trimetrexate.
Prophylaxis of pneumocystis pneumonia is not a labeled indication. 25 mg, orally, once a week, in combination with dapsone and pyrimethamine Comments: 1. Prophylaxis in HIV infected patients usually begins when the CD4+ count is less than 200 cells/mm or for a history of oropharyngeal candidiasis. 2. Prophylaxis is usually discontinued when CD4+ co...
Use in the treatment of toxoplasmosis is not a labeled indication. Ocular toxoplasmosis: 5 to 25 mg orally, IV, or IM, with each dose of pyrimethamine Acute/primary treatment of toxoplasma encephalitis in AIDS patients: Standard dose: 10 to 20 mg, orally, IM, or IV, once a day, during and for 1 week after pyrimethamine treatment Maximum dose: 50 mg...
Leucovorin Rescue: 15 mg (approximately 10 mg/m2), orally, IV, or IM, every 6 hours for 10 doses; start 24 hours after beginning of methotrexate infusion (based on a methotrexate dose of 12 to 15 g/m2 IV over 4 hours) Impaired Methotrexate Elimination or Inadvertent Overdosage: 10 mg/m2 orally, IV, or IM, every 6 hours until methotrexate level is l...
Leucovorin Rescue for Methotrexate (MTX): 1. Normal MTX elimination (MTX approximately 10 micromol 24 hours after administration, 1 micromol at 48 hours, and less than 0.2 micromol at 72 hours): Leucovorin 15 mg oral, IM, or IV every 6 hours for 60 hours (10 doses) 2. Delayed late MTX elimination (MTX above 0.2 micromol at 72 hours, and more than 0...
Administration advice: 1. Do not administer intrathecally; may be harmful or fatal if given intrathecally. 2. Because of the calcium content of the solution, no more than 160 mg should be injected intravenously per minute (16 mL of a 10 mg/mL, or 8 mL of a 20 mg/mL solution per minute). 1. Because of the benzyl alcohol in certain diluents, when adm...
Leucovorin is a folate analog used to enhance the effects of methotrexate and other antimetabolites. Learn about the dosage, indications, and side effects of leucovorin rescue for methotrexate overdose or impaired elimination.
Leucovorin rescue is a cornerstone for toxicity prevention in HDMTX treatment. However, the leucovorin dose adjustment and the existence of leucovorin overrescue are still controversial. At present, various methods for calculating leucovorin doses in different tumour types have been proposed, including empirical calculations based on MTX plasma ...
Aug 5, 2016 · Leucovorin dosing must be increased dramatically when plasma MTX levels are elevated above 5 µM at 42 hours after the start of the MTX infusion because leucovorin must compete with MTX to enter cells via the reduced folate carrier and the goal of leucovorin rescue is to achieve a high intracellular concentration of leucovorin.
- Scott C. Howard, John McCormick, Ching-Hon Pui, Randall K. Buddington, R. Donald Harvey
- 10.1634/theoncologist.2015-0164
- 2016
- Oncologist. 2016 Dec; 21(12): 1471-1482.
Jan 17, 2007 · GENERAL GUIDELINES FOR MODIFICATION OF LEUCOVORIN (LV) DOSAGE FOLLOWING HIGH DOSE METHOTREXATE Time after the START of infusion Serum creatinine Methotrexate level Action At 24 hrs If methotrexate is infused as a short infusion (over 0.5 - 6 hours), and level GREATER than 5 micromol/L 1) INCREASE LV to 100 mg/m2 IV Q6H.
Sep 23, 2022 · Prolonged, persistent, or increased plasma levels of MTX are a consequence and may result in inefficient leucovorin rescue and a significant increase in MTX-related toxicities. The precipitation of MTX and its metabolites in the renal tubules was assumed to be the cause of renal impairment, although this is challenged by the finding that MTX ...
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related to: leucovorin rescueGet An Earlier Start On Inadequate MTX Elimination Due To Impaired Renal Function. Learn More About Treating High-Dose Methotrexate Toxicity And Its Symptoms.
(fam-trastuzumab deruxtecan-nxki). Read The PI & Boxed Warnings on Patient Website. ENHERTU Is Now Approved For More Patients. Visit Site To Learn More.
(fam-trastuzumab deruxtecan-nxki). Read The PI & Boxed Warnings on Physician Website. Learn About How ENHERTU® May Help Your Patients. Approved For a New Indication.
