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- Prognosis: good with use of drugs although most likely to improve as opposed to normalize the condition.
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What is the prognosis of myotonia in dogs?
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Myotonia congenita is an autosomal recessive disease that can be seen in Cavalier King Charles Spaniels, Chow Chows, Rhodesian Ridgebacks, Australian Cattle dogs, Jack Russell Terriers, Miniature Schnauzers, and Staffordshire Bull Terriers. Chloride channels typically allow proper conduction of electrical impulses from the nerves to the muscles.
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Few reports have indicated the prognosis of dogs with myotonia associated with HAC. According to one study ( 11 ), the median survival time for dogs with pituitary-dependent HAC treated with trilostane was 662 d (range: 8 to 1971 d).
- Noriyuki Nagata, Masashi Yuki
- 2015
May 30, 2017 · The nondystrophic myotonic syndromes are caused by conventional point mutations or deletions in the genes that encode skeletal muscle chloride or sodium channels.47 These include myotonia congenita, caused by mutations in the skeletal muscle chloride channel gene, CLCN1, and paramyotonia congenita, hyperkalemic periodic paralysis (HyperPP), and ...
- M. Lowrie, L. Garosi
- 2017
Dec 20, 2005 · Myotonia Congenita is a hereditary, skeletal muscle disorder. Mytonic puppies exhibit clinical signs at a few weeks of age because their muscles are hyperexcitable and contract easily. Affected dogs have prominent muscles in the shoulders and thighs and appear to have difficulty getting up, have a stiff gait, or bunny hop when running.
May 11, 2018 · This study expands the spectrum of identified canine CLCN1 mutations and the list of affected breeds in myotonia congenita and highlights the potential value of dogs as translational large animal models of human genetic diseases.
Dogs with myotonia exhibit a stiff gait, experience trouble when rising, often suffer swollen tongues and may have difficulty swallowing. Young dogs start to show symptoms as early as of a few weeks of age. Diagnosis of Myotonia in Dogs. Diagnosis is based on the history and physical examination findings as well as consideration of the following:
Aug 28, 2023 · Myotonia congenita (MC) is a genetic neuromuscular channelopathy which usually presents in early childhood resulting in a delay of skeletal muscle relaxation following contraction. MC has many implications for patients and their families, including impaired locomotion, swallowing, gastrointestinal disturbance, and respiratory complications.
