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May 15, 2024 · Pregnancy and childbirth. With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman's health care providers to be aware that she has VWD so that plans can be made for a ...
Thus, women with VWD should start pregnancy after being well characterized as to their type, subtype, and treatments. Women with VWD who have VWF and FVIII basal levels >30 U/dL typically normalize these levels at the end of pregnancy and specific anti-hemorrhagic prophylaxis is seldom required.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
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May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
James AH, Jamison MG. Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. J Thromb Haemost. 2007;5(6):1165-1169. James AH, Konkle BA, Kouides P, et al. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.
- What Is Von Willebrand Disease?
- What Happens If You Have Von Willebrand Disease?
- How Common Is This condition?
von Willebrand disease is a common blood disorder that keeps your blood from clotting. This is an inherited disorder, meaning parents may pass the disorder on to their biological children. Healthcare providers treat this disorder with medication to help with blood clotting.
People with von Willebrand disease may bleed more than usual. For example, they may have frequent nosebleeds or bleed for a long time after getting a minor cut. Women or people designated female at birth (DFAB) may have heavy menstrual periods or heavy bleeding after giving birth. People who have the most serious form of von Willebrand disease may ...
von Willebrand disease affects 1% of the U.S. population and is the most common bleeding disorder in the United States. Globally, von Willebrand disease affects an estimated 23 to 110 in 1 million people. The numbers vary because people may have bleeding issues, but aren’t diagnosed with von Willebrand disease. In some cases, people have had bleedi...
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
Von Willebrand factor is an acute phase reactant, and plasma levels may be high during stress, in pregnant women, and in newborns after vaginal delivery. The levels may be reduced in hypothyroid patients but return to normal when patients become euthyroid. Von Willebrand factor is a large, multimeric glycoprotein encoded on chromosome 12.
