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Increased risk of bleeding events
- Although women with VWD do not appear to be at an increased risk of poor fetal outcomes, they are at an increased risk of bleeding events and possibly death during pregnancy and childbirth.
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However, there are also instances during pregnancy (amniocentesis, vaginal bleeding associated with placental detachment, sudden abortion) that may require urgent hemostatic treatment to prevent bleeding. Thus, women with VWD should start pregnancy after being well characterized as to their type, subtype, and treatments.
- Table 1
Given the wide heterogeneity of phenotypes and of the...
- Mcmdm-1Vwd
Introduction. von Willebrand factor (VWF) is a multimeric...
- Table 1
Jun 7, 2022 · Although VWD occurs equally in males and females, women are at a higher risk of being affected, mostly because of bleeding challenges associated with menstruation, pregnancy, and childbirth [ 1, 7, 8 ]. During pregnancy, many changes in hemostasis occur that result in a hypercoagulable state.
May 20, 2019 · In general, VWD patients should be monitored for VWF:RCo and FVIII:C at least once during the third trimester of pregnancy. 2 The risk of bleeding is minimal when FVIII:C and VWF:RCo levels without treatment during pregnancy are higher than 50 U/dL. 1, 4, 30, 32 However, the risk of bleeding is highest in those who do not self-correct, even if ...
- Giancarlo Castaman, Paula D. James
- 2019
Seattle, Washington. Download PDF. H&O How common is von Willebrand disease (VWD)? JJ VWD is the most common inherited bleeding disorder, with an incidence of approximately 1 per 1000 people. It has an autosomal inheritance pattern, so men and women are equally likely to be affected.
Nov 16, 2006 · OBJECTIVE: Case reports and case series suggest that women with von Willebrand disease (VWD) are at an increased risk of bleeding and other complications during pregnancy, delivery and the postpartum period.
- Andra H. James, Margaret G. Jamison
- 2006
May 15, 2024 · Women with VWD are at risk for serious bleeding after delivery. During any pregnancy, the body makes higher amounts of clotting factors to prevent bleeding. However, the high levels of clotting factors during pregnancy drop back to lower levels after delivery.
Bleeding events and other complications during pregnancy and childbirth in women with von Willebrand disease. Summary. Background: Case reports and case series suggest that women with von Willebrand disease (VWD) are at an increased risk of bleeding complications during pregnancy and delivery.
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related to: Does von Willebrand disease cause bleeding events during pregnancy and childbirth?Visit the HCP site to view safety information for a treatment for VWD in adults.
