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- Indeed, the work of Christian de Duve led to an explosion in cell biology, with the discovery of lyso-somes and peroxisomes and of their function. From the deciphering of the physiopathology of lysosomes followed the first molecular explanation of an intracellular genetic disorder, Pompe's glycogenosis, the prototype of lysosomal storage diseases.
www.ncbi.nlm.nih.gov › pmc › articlesA TRIBUTE TO Professor Christian de Duve on his 90th birthday
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Aug 1, 1998 · Within the short span of a few decades, a revolution occurred in cell biology. Those responsible for this revolution were a small band of researchers who applied to the study of cells the emerging technologies of electron microscopy and fractionation by high-speed centrifugation coupled with biochemical analysis.
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Initially, I studied biochemistry at Tübingen University,...
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Oct 1, 2013 · Christian de Duve, age 95, presenting his ideas on the origin of the eukaryotic cell (October 2012). Image credit: Julien Doornaert . Christian de Duve was an internationally renowned cell biologist whose serendipitous observation while investigating the workings of insulin led to groundbreaking insights into the organization of the cell.
- Frederik Opperdoes
- 10.1371/journal.pbio.1001671
- 2013
- PLoS Biol. 2013 Oct; 11(10): e1001671.
Aug 8, 2013 · De Duve was the last of a group of eminent physiological chemists who, by the 1940s and 1950s, began to explore the subcellular organization of biochemical pathways and thus forged the emergence of Modern Cell Biology. Christian De Duve, Albert Claude, and George Palade received the Nobel Prize in 1974 “for their discoveries concerning the ...
- David D. Sabatini, Milton Adesnik
- 10.1073/pnas.1312084110
- 2013
- 2013/08/08
May 4, 2013. De Duve was the last of a group of eminent physiological chemists who, by the 1940s and 1950s, began to explore the subcellular organizatio n of biochemical path-ways and thus forged the emergence of Modern Cell Biology. Christian De Duve, Albert Claude, and George Palade received the Nobel Prize in 1974 “for their discoveries
Jun 19, 2013 · On route to this goal, he revolutionized cell research by experimenting with two recently developed instruments: the electron microscope and the high-speed centrifuge. The electron microscope...
- Günter Blobel
- blobel@mail.rockefeller.edu
- 2013
The Discovery of Lysosomes. In 1949, Christian de Duve, then chairman of the Laboratory of Physiological Chemistry at the University of Louvain in Belgium, was studying how insulin acted on liver...
This change of direction was inspired by a chance observation that would change our understanding of the structural and functional organization of the cell: de Duve noticed that the activity of the liver enzyme glucose-6-phosphatase was mostly associated with a sedimentable cell fraction called microsomes, which mainly contained vesicles of the ...
