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   How many neonates are needed to treat sepsis?

   • The number needed to treat (NNT) was 37 to prevent the use of antibiotics in one neonate. An additional meta-analysis using many of the same studies confirmed the findings related to antibiotic use. 2 Five of the studies reported data on laboratory testing for early-onset sepsis and included 168,432 neonates.

   Neonatal Early-Onset Sepsis Calculator | AAFP

   www.aafp.org/pubs/afp/issues/2021/1200/p636.html

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   Does early onset sepsis calculator implementation reduce healthcare utilization and costs?

   • Early onset sepsis calculator implementation is associated with reduced healthcare utilization and financial costs in late preterm and term newborns. Eur J Pediatr. 2020;179:727‐734.

   Neonatal early‐onset sepsis calculator recommended

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7754364/

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   What is a sepsis calculator?

   • The sepsis calculator is the most often used strategy in the USA and has been incorporated into clinical practices throughout the world. It uses continuous and categorical variables (as described below) and the infant’s clinical condition in the first 6–12 hours of life to estimate the risk of sepsis.

   What’s new in the management of neonatal early-onset sepsis?

   fn.bmj.com/content/108/1/10

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2. jamanetwork.com › journals › jamanetworkopenAntibiotic Use in Late Preterm and Full-Term Newborns

   jamanetwork.com › journals › jamanetworkopen

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   Mar 22, 2024 · Achten NB, Klingenberg C, Benitz WE, et al. Association of use of the neonatal early-onset sepsis calculator with reduction in antibiotic therapy and safety: a systematic review and meta-analysis. JAMA Pediatr. 2019;173 (11):1032-1040. doi: PubMed Google Scholar Crossref.

3. www.pediatr-neonatol.com › article › S1875-9572(23Neonatal early-onset sepsis calculator: Impact on antibiotic ...

   www.pediatr-neonatol.com › article › S1875-9572(23

   Aug 23, 2023 · The Kaiser Permanente neonatal early-onset sepsis (EOS) calculator is an evidence-based sepsis risk assessment tool that has demonstrated potential to reduce antibiotic usage in this population. The incidence of early-onset sepsis in most HICs is 0.4–0.8 per 1000 live births.

4. www.aafp.org › pubs › afpNeonatal Early-Onset Sepsis Calculator | AAFP

   www.aafp.org › pubs › afp

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   Although there is the potential for missing culture-positive sepsis or delaying antibiotic administration with the CDC guideline and the sepsis calculator, there is an opportunity to...

5. publications.aap.org › pediatrics › articleImproving the Evaluation and Management of Early Onset Sepsis ...

   publications.aap.org › pediatrics › article

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   Feb 23, 2022 · Antibiotics are frequently used during sepsis evaluation. There is evidence associating early antibiotic use with long-term adverse effects. Research has now shown that use of the Kaiser Permanente neonatal sepsis calculator can reduce antibiotic use and unnecessary sepsis evaluation.

6. fn.bmj.com › content › 108/1/10What’s new in the management of neonatal early-onset sepsis?

   fn.bmj.com › content › 108/1/10

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   Use of the sepsis calculator has been shown to reduce the use of antibiotics, laboratory testing and admission to the intensive care unit16 but misses a substantial proportion of infants with EOS.15 The serial observation approach has also been shown to reduce the use of antibiotics but is labour intensive.17 Categorial risk assessment as ...

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8. www.pediatr-neonatol.com › article › S1875-9572(23Neonatal early-onset sepsis calculator: Impact on antibiotic ...

   www.pediatr-neonatol.com › article › S1875-9572(23

   Aug 24, 2023 · The Kaiser Permanente neonatal early-onset sepsis (EOS) calculator is an evidence-based sepsis risk assessment tool that has demonstrated potential to reduce antibiotic usage in this population. The incidence of early-onset sepsis in. per 1000 live births. The objective was to evaluate the calculator’s impact.

9. www.sciencedirect.com › science › articleNeonatal early-onset sepsis calculator: Impact on antibiotic ...

   www.sciencedirect.com › science › article

   Jan 1, 2024 · The Kaiser Permanente neonatal early-onset sepsis (EOS) calculator is an evidence-based sepsis risk assessment tool that has demonstrated potential to reduce antibiotic usage in this population. The incidence of early-onset sepsis in most HICs is 0.4–0.8 per 1000 live births.