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Oct 6, 2019 · discovered that rosiglitazone passes through the placenta at a low rate, and there is minimal fetal accumulation and transfer of rosiglitazone in the placenta. [ 89] measure the transfer of lamivudine across the human placenta ex vivo. by simple diffusion, lamivudine appears to pass over the placenta.
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discovered that rosiglitazone passes through the placenta at...
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Microengineered barrier exposure to caffeine: (a1,a2)...
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The hemotrichorial mouse placenta places maternal and fetal...
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Abstract. The placenta is a multi-functional organ that exchanges blood gases and nutrients between a mother and her developing fetus. In humans, fetal blood flows through intricate networks of vessels confined within villous trees, the branches of which are bathed in pools of maternal blood.
- Oliver E. Jensen, Igor L. Chernyavsky
- 2019/01
- 10.1146/annurev-fluid-010518-040219
People also ask
Where do chorionic arteries enter the placenta?
How do nutrient and drug transfer occur across the placenta?
Where does maternal blood enter the placenta?
Maternal blood traverses through the placenta intervillous space and drains back through venous orifices in the basal plate, then returns the maternal systemic circulation via uterine veins.
- Yuping Wang, Shuang Zhao
- 2010
- 2010
Feb 12, 2021 · Nutrients and oxygen from the mother's blood pass into the baby's bloodstream through the placenta. Meanwhile, the baby excretes carbon dioxide and waste products through the umbilical blood vessels. But the blood of the fetus and the blood of the mother never meet.
- Placental Structure
- Functions of The Placenta
- Placental Drug Transfer
- Summary
The placenta is a disc-shaped organ which provides the sole physical link between mother and fetus. During pregnancy, the placenta grows to provide an ever-larger surface area for materno-fetal exchange. At term, the placenta weighs almost 500 g, has a diameter of 15–20 cm, a thickness of 2–3 cm, and a surface area of almost 15 m2.1 The basic struc...
Gas exchange
The fetal lungs do not take part in gas exchange while in utero, so the placenta is wholly responsible for the transfer of oxygen and carbon dioxide to and from the developing fetus.
Endocrine function
The placenta is an endocrine organ which produces a number of important peptide and steroid hormones.
Immunological function
Although most proteins are too large to cross the placental barrier, maternal IgG antibodies may cross from mother to fetus by pinocytosis to provide passive immunity in the first few months of life. The syncytiotrophoblast possesses receptors for the Fc fragments of IgG; the bound IgG is then endocytosed into a vesicle before being released by exocytosis into the fetal blood.2 This transfer starts in early gestation and increases exponentially in the third trimester.7 Antibodies which cause...
Almost all drugs will eventually cross the placenta to reach the fetus. In some cases, this transplacental transfer may be beneficial and drugs may be deliberately administered to the mother in order to treat specific fetal conditions. For example, steroids may be given to the mother to promote fetal lung maturation and cardiac drugs may be given t...
The placenta is a remarkable organ which plays a vital role in ensuring the satisfactory growth and development of the fetus. Further research is required to increase our understanding of the molecular mechanisms of transplacental drug transfer, and the ways in which drugs may impact on fetal health and wellbeing.
- Sarah K Griffiths, Jeremy P Campbell
- 2015
Your blood passes through the placenta and provides oxygen, glucose and nutrients to your baby through the umbilical cord. The placenta can also filter out harmful waste and carbon dioxide from your baby's blood. The placenta enables the exchange of oxygen and nutrients between the bloodstreams of you and your baby without ever mixing them.
The placenta has the capability to selectively transfer drugs and metabolic products in either direction rapidly and completely or to a limited extent. The transfer is based on molecular weight, pH, protein binding, lipophilicity, and type of transfer.
