Search results
People also ask
Is CLOVES syndrome related to other overgrowth disorders?
What is CLOVE syndrome?
Is CLOVES syndrome a PIK3CA-related overgrowth syndrome?
CLOVES syndrome is a rare overgrowth syndrome with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs.
CLOVES syndrome characterized by Congenital Lipomatous Overgrowth, Vascular malformations, Epidermal nevi, and Skeletal anomalies is a recently described sporadic syndrome from postzygotic activating mutations in PIK3CA. This 3-year-old boy, born to nonconsanguineous and healthy parents, had epidermal verrucous nevus, lower limb length ...
- Vikram K Mahajan, Mrinal Gupta, Pushpinder Chauhan, Karaninder S Mehta
- 10.4103/idoj.IDOJ_418_18
- 2019
- Jul-Aug 2019
CLOVES syndrome is a rare condition that is primarily characterized by congenital overgrowth of fatty tissue; malformations of the vascular system (the vessels that carry blood and lymph throughout the body); epidermal nevi; and spinal or skeletal abnormalities.
Children with CLOVES syndrome are often mistakenly diagnosed as having other disorders that cause overgrowth of the blood vessels and abnormalities in certain parts of the body, such as: Hemihypertrophy: a condition in which the structures on one side of a child’s body are larger than on the other
- Cloves Syndrome Symptoms
- Causes
- Diagnosis
- Treatment
- Prognosis
- Summary
- A Word from Verywell
- Frequently Asked Questions
CLOVES syndrome affects the body’s tissue, blood vessels, bones, and some internal organs. Its symptoms are usually recognizable at birth or shortly after. Some of the most common symptoms include: 1. Fatty tissue overgrowth:Soft lumps—also called lipomas—that form under the skin are often found on the stomach, back, and sides of CLOVES syndrome pa...
CLOVES syndrome is caused by a gene mutation (a change) that is thought to happen during the baby’s early development in the womb. Genesare responsible for determining a person’s features or traits. In CLOVES syndrome, a change happens in the gene known as PIK3CA. It is a growth regulatory gene, meaning it plays an important role in instructing the...
To diagnose CLOVES syndrome, a doctor will start by looking for its signature combination of skin, blood vessel, and spinal problems. This can be done through a physical exam. From there, a suspected CLOVES syndrome diagnosis can be confirmed through the following methods: 1. Imaging:X-ray or magnetic resonance imaging(MRI) gives the doctor an insi...
There is currently no cure for CLOVES syndrome, but a team of doctors can help treat and manage the various symptoms that it causes. Depending on the specific case, this medical team can include a general surgeon, geneticist, radiologist (a doctor who specializes in imaging like X-rays), hematologist(a doctor who specializes in blood disorders), an...
Each case of CLOVES syndrome is different, so outcomes will vary in part based on how old the child is when diagnosed and how serious the symptoms are. One thing that all CLOVES syndrome cases have in common is the importance of getting diagnosed as early as possible. The sooner that CLOVES can be diagnosed, evaluated, and treated, the better the g...
CLOVES syndrome is a rare condition that a person is born with. It causes issues with skin overgrowths, blood vessels, and the spine. The underlying cause is a gene mutation that is not inherited. It is diagnosed by physical examination and imaging. Treatment depends on the symptoms the person has, which vary from case to case and may include medic...
CLOVES syndrome is not only very rare, but it’s also very new for scientists and researchers, who are studying this condition and potential new treatments. There are still many unknowns about CLOVES syndrome and the complications it causes. Experts are encouraged by the fact that many children with CLOVES can live healthy, normal lives with routine...
How many children have CLOVES syndrome?
CLOVES syndrome is very rare. Fewer than 200 cases have been reported worldwide. Based on that data, researchers think that CLOVES affects males and females of all ages, races, and ethnicities equally.
How do doctors test for CLOVES syndrome before birth?
Doctors can sometimes detect blood vessel overgrowth, fatty tissue, and spinal issues through an ultrasound while the baby is still in the womb. Otherwise, CLOVES syndrome can be diagnosed at birth.
What does CLOVES syndrome treatment involve?
Treatment will vary based on the specific symptoms. Some common options include: oral medication for blood vessel abnormalities, surgery to remove fatty tissue overgrowths, and orthopedic support for issues with the bones.
- Cristina Mutchler
Aug 5, 2020 · CLOVES syndrome belongs to the spectrum of overgrowth syndromes with complex vascular anomalies caused by mosaic mutations in the gene. CLOVES syndrome may affect the soft tissue, blood vessels, bone and internal organs. The manifestations are very variable ranging from mild to severe anomalies.
CLOVES syndrome is caused by a somatic mosaic gain-of-function mutation (a mutation that occurs after the creation of the zygote) in the PIK3CA gene [2]. It is a part of the PIK3CA-Related Overgrowth Spectrum (PROS), a group of rare overgrowth disorders [3].
