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- A meta-analysis of six high-quality non-randomized controlled trials and 172,385 neonates evaluated the sepsis calculator vs. the standard approach recommended by CDC guidelines for management of early-onset sepsis. 1 All studies were published in 2017 or later and reported a statistically significant reduction in antibiotic use in neonates who were treated using the sepsis calculator compared with the standard approach (3.3% vs. 6%; odds ratio [OR] = 0.22; 95% CI, 0.14 to 0.36; P <.00001).
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Is sepsis calculator for Eos a randomized controlled trial?
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Can the neonatal early-onset sepsis calculator safely and accurately evaluate the risk of early-onset sepsis in neonates?
Sep 3, 2019 · The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on the effectiveness and safety of the EOS calculator is essential to inform clinicians considering implementation.
- Niek B. Achten, Claus Klingenberg, William E. Benitz, Martin Stocker, Luregn J. Schlapbach, Luregn J...
- 10.1001/jamapediatrics.2019.2825
- 2019
- JAMA Pediatr. 2019 Nov; 173(11): 1032-1040.
Dec 22, 2019 · Determining which babies should receive antibiotics for potential early onset sepsis (EOS) is challenging. We performed a meta-analysis quantifying how many EOS cases might be ‘missed’ using the Kaiser Permanente electronic calculator, compared with National Institute for Health and Care Excellence (NICE) guidelines.
- Katherine J. Pettinger, Katie Mayers, Liz McKechnie, Bob Phillips
- 2020
The purpose of the current systematic review and meta-analysis was to identify, critically appraise, and synthesize evidence from studies comparing management guided by the EOS calculator with conventional management strategies, and report the rates of empirical antibiotic therapy for suspected EOS.
- Niek B. Achten, Claus Klingenberg, William E. Benitz, Martin Stocker, Luregn J. Schlapbach, Luregn J...
- 2019
Apr 21, 2021 · The EOS risk calculator provides an early-onset sepsis risk estimate for each neonate based on the five objective maternal risk factors and four clinical neonatal risk factors. It categorized neonates into three levels of risk with a correlated recommendation, like laboratory tests, start or not to start antibiotic treatment.
- Roya Huseynova, Latifa Bin Mahmoud, Fahad Hamad Aljobair, Ogtay Huseynov, Halima Career, Parameaswar...
- 10.7759/cureus.14620
- 2021
- Cureus. 2021 Apr; 13(4): e14620.
Objective: To compare outcomes of neonatal EOS using of sepsis calculator versus conventional approach. Methods: A systematic review of randomized controlled trials (RCT) and non-RCTs reporting on outcomes after implementation of sepsis calculator for EOS for neonates >34-week gestation was conducted using the Cochrane methodology.
This model was modified into an interactive EOS calculator that combines individual risk as-sessments with clinical recommendations for managing neonates.2 A meta-analysis and systematic review contained good evidence in favour of the EOS calculator for reducing antibiotic therapy, but lim-ited evidence for non-inferiority of the EOS calculator ...
