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Although CZS can present with a broad spectrum of ocular findings, the most distinctive are the pigment mottling and chorioretinal atrophy that are commonly seen in the macular region. 10, 11, 14, 15 These ocular findings were first described after being identified in infants from the state of Pernambuco, which is located in northeastern Brazil ...
In Brazil, investigators have reported macular and optic nerve abnormalities in a study of 29 infants with microencephaly due to a possible Zika congenital infection, 3 and in an earlier study of 3 infants. 4 The findings included gross macular pigment mottling, macular chorioretinal atrophy, optic nerve hypoplasia, increased cup-to-disc ratio, ...
Ocular anomalies have been reported in infants with presumed and laboratory-confirmed prenatal Zika virus (ZIKV) infection [1 ,2 ,3,4 ,5]. Posterior findings have been the most prevalent, but some studies have reported that anterior segment and structural defects also might be related [2 ,4 ,5] .
Of the 24 infants tested, 100% had positive results for ZIKV infection: 14 of 22 infants (63.6%) from the group with ophthalmoscopic findings and 10 of 18 infants (55.6%) from the group without ophthalmoscopic findings.
- Camila V. Ventura, Mauricio Maia, Simone B. Travassos, Thayze T. Martins, Felipe Patriota, Marcos Eu...
- 2016
In the series described by de Paula Freitas and colleagues, almost 80% of mothers reported symptoms consistent with Zika virus infection, most in the first trimester. 4 Ocular abnormalities were present in 10 of the 29 infants examined (35%) and were bilateral in 7 of the 10.
Zika virus infection can occur in infants, children, and adults and may affect ocular structures. Acute Zika virus infection is usually asymptomatic. Symptoms if present are mild and include maculopapular rash, fever, arthralgia, and/or non-purulent conjunctivitis. In rare cases, neurological complications have occurred.
