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What is fixed drug eruption (FDE)?
What causes a fixed-drug eruption?
Are fixed drug eruptions associated with causative drug or patient risk factors?
Where does a fixed drug eruption occur?
What causes fixed drug eruption? Fixed drug eruption is a delayed type IV hypersensitivity reaction. In the initial phase memory CD8+ T-cells at the dermo- epidermal junction release interferon-gamma when activated by the medication antigen causing epidermal basal layer damage.
Apr 8, 2024 · Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same locations upon re-exposure to the offending drug. Acute FDE usually presents with a single or a small number of dusky red or violaceous plaques that resolve leaving postinflammatory hyperpigmentation ( picture 1A-C ).
Oct 9, 2020 · The major categories of causative agents of fixed drug eruption include antibiotics, antiepileptics, nonsteroidal anti-inflammatory agents, sildenafil, and phenothiazines, although numerous other...
Sep 1, 2021 · Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by the onset of rash at a fixed location on the body each time a specific medication is ingested. With each recurrence, the eruption can involve additional sites.
- Hannah J Anderson, Jason B Lee
- 10.3390/medicina57090925
- 2021
- Medicina (Kaunas). 2021 Sep; 57(9): 925.
Fixed drug eruption (FDE) is a well-defined, circular, hyperpigmenting plaque that recurs as one or a few lesions always in fixed locations upon ingestion of a drug. FDE commonly occurs on the genitals, lips, trunk, and hands.
- Hal Flowers, Robert Brodell, Melissa Brents, Julie Porter Wyatt
- 2014
A fixed-drug eruption (FDE) is an immunological cutaneous adverse reaction characterized by sharply defined lichenoid lesion/s which occur/s at the same location every time there is exposure to the causative substance. Exogenous agents are the only known cause of FDE.
Aug 23, 2022 · Fixed drug eruptions (FDEs) are dermatological manifestations of drug reactions that often occur in the same location upon re-exposure to a drug. They usually appear as erythematous-violaceous, circular patches, but several different variants have been described.
