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Nov 20, 2023 · Castleman disease, also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia, is an uncommon benign B-cell lymphoproliferative condition. It can affect several regions of the body but is commonly described as a solitary mediastinal mass.
Unicentric Castleman disease (UCD) involves a single enlarged lymph node or multiple enlarged lymph nodes within a single region of the body that display microscopic features consistent with Castleman disease. It is also sometimes called localized Castleman disease.
Apr 21, 2022 · Unicentric CD (UCD) involves one or more enlarged lymph node(s) in a single region of the body that demonstrates CD histopathologic features that lie along a spectrum with hyaline vascular histopathologic subtype on one end, plasmacytic histopathologic subtype on the other, and a "mixed" subtype in the middle. A subset of patients have systemic ...
Jan 17, 2019 · Specifically, it is defined as a follicular hyperplasia of lymph nodes with abnormally increased vascularity. It can be classified as unicentric or multicentric based on radiological...
Unicentric Castleman disease is a subtype of Castleman disease (also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of lymphoproliferative disorders characterized by lymph node enlargement, characteristic features on microscopic analysis of enlarged lymph node tissue, and a range ...
Apr 21, 2022 · Castleman disease (CD, angiofollicular lymph node hyperplasia) describes a heterogeneous group of lymphoproliferative disorders that share common histopathologic features.
Unicentric CD typically manifests as an asymptomatic lymph node or group of nodes in a single region of the body. Rarely, it is accompanied by systemic symptoms. 27 , 28 Multicentric CD can be associated with human herpesvirus 8 (HHV-8; often in HIV-infected individuals) or idiopathic.
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