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  1. www.ncbi.nlm.nih.gov › books › NBK470526Nitrofurantoin - StatPearls - NCBI Bookshelf

    May 29, 2023 · Nitrofurantoin was widely used to treat lower urinary tract infections until the 1970s, when trimethoprim-sulfamethoxazole and newer beta-lactam antibiotics became available. Several major guidelines have recently declared nitrofurantoin the first-line therapy for treating uncomplicated lower urinary tract infections.

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  3. www.ncbi.nlm.nih.gov › pmc › articlesNitrofurantoin: properties and potential in treatment of ...

    Jul 27, 2023 · Nitrofurantoin (NF), a wide-spectrum antibiotic accessible since 1953, is utilized widely to treat urinary tract infections as it usually stays active against drug-resistant uropathogen.

    • 10.3389/fcimb.2023.1148603
    • 2023

  4. www.clinicalmicrobiologyandinfection.com › articleNitrofurantoin's efficacy and safety as prophylaxis for ...

    Aug 18, 2016 · After its approval by the US Food and Drug Administration in 1953, nitrofurantoin became standard therapy for lower urinary tract infections (UTI) until the late 1970s, when other antibiotics became available and its use decreased substantially.

    • Anouk E Muller, Els M Verhaegh, Stéphan Juergen Harbarth, Johan W Mouton, Angela Csaki Huttner
    • 2017

  5. www.ncbi.nlm.nih.gov › pmc › articlesKidney function and the use of nitrofurantoin to treat ...

    Jun 6, 2015 · Nitrofurantoin is currently considered unsuitable for patients with reduced estimated glomerular filtration rate. 7 In this study, nitrofurantoin was the antibiotic most commonly prescribed for urinary tract infection in older women, irrespective of estimated glomerular filtration rate.

    • Namisha Singh, Sonja Gandhi, Eric McArthur, Louise Moist, Arsh K. Jain, Aiden R. Liu, Manish M. Sood...
    • 2015

  6. pubmed.ncbi.nlm.nih.gov › 33535221The Clinical Efficacy of Nitrofurantoin for Treating ... - PubMed

    Objective: To provide an updated systematic review of randomized control trials (RCTs) to investigate the clinical and microbiological efficacy of nitrofurantoin compared to other antibiotics or placebo for treatment of uncomplicated urinary tract infections (uUTI).

    • Angelo Porreca, Daniele D'Agostino, Daniele Romagnoli, Francesco Del Giudice, Martina Maggi, Katie P...
    • 2021

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  8. academic.oup.com › jac › articleNitrofurantoin revisited: a systematic review and meta ...

    Jun 11, 2015 · 11 June 2015. Article history. PDF. Split View. Cite. Permissions. Share. Abstract. Objectives. Nitrofurantoin's use has increased exponentially since recent guidelines repositioned it as first-line therapy for uncomplicated lower urinary tract infection (UTI).

  9. www.mayoclinicproceedings.org › article › S0025-6196School of Medicine - Mayo Clinic Proceedings

    We agree that nitrofuran-toin should have a major contemporary role in outpatient treatment of uncomplicated UTIs in the United States and worldwide.1 Dr Cunha noted one known mechanism of action of nitrofurantoin; we add that the mechanism of bactericidal activity of nitrofurantoin remains unclear and that other mechanisms, including bacterial ...