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Is azithromycin a broad-spectrum pharmacological profile?
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How has our perception of azithromycin evolved over the last 50 years?
How does azithromycin work?
Azithromycin is an azalide, a type of macrolide antibiotic. It works by decreasing the production of protein, thereby stopping bacterial growth. Azithromycin was discovered in Croatia in 1980 by the pharmaceutical company Pliva and approved for medical use in 1988.
Dec 12, 2020 · The end of the 20th century saw the establishment of macrolides as a powerful class of anti-inflammatory antibiotics for respiratory diseases. In the decades since, progressive clinical and in vitro studies have been indicative of a growing acknowledgement for azithromycin’s broad-spectrum pharmacological profile.
- Anton Firth, Praveen Prathapan
- 10.1016/j.ejmech.2020.112739
- 2020
- Eur J Med Chem. 2020 Dec 1; 207: 112739.
Sep 1, 2016 · Discovery of the first 15-membered macrolide—azithromycin, characterized by a basic nitrogen atom inserted into the macrocyclic ring, represented a breakthrough in the macrolide antibiotic era. Azithromycin became one of the best-selling branded antibiotics worldwide.
- Dubravko Jelić, Roberto Antolović
- 10.3390/antibiotics5030029
- 2016
- Antibiotics (Basel). 2016 Sep; 5(3): 29.
Dec 1, 2011 · The azithromycin (i.e. Sumamed and Zithromax) story, which dates from the second half of the last century, can be considered as the first and foremost example of successful knowledge and...
Dec 1, 2020 · Since its first administration as a prophylaxis for malaria in 1998, azithromycin has been discovered to cause a stronger impairment of lysosomal acidification compared to chloroquine [76].
- Anton Firth, Praveen Prathapan
- 2020
Jan 15, 2023 · Azithromycin is an antimicrobial medication used to treat and manage bacterial infections, including community-acquired pneumonia and sexually transmitted diseases. It is in the macrolide class of antimicrobials.
The azithromycin (i.e. Sumamed and Zithromax) story, which dates from the second half of the last century, can be considered as the first and foremost example of successful knowledge and technology transfer in Croatia ever.
