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Jul 12, 2023 · Clarithromycin isn't generally recommended in pregnant females due to the potential risk for problems (e.g., heart problems, cleft palate) seen in animal studies. The risk of harm to human babies isn't completely clear. A 2021 human study found that babies born to pregnant
Methods and results: In a detailed literature search, we found 15 women, five men, and one boy meeting our search criteria. Among the 17 adults with reported clarithromycin dose and concurrent QTc interval measurement, we found no statistically significant relationship between clarithromycin dose and QTc interval duration.
Oct 24, 2023 · Clarithromycin is a macrolide antibiotic and is not typically used to treat UTI's. Common antibiotics used to treat the bacteria that usually cause urinary tract infections include trimethoprim-sulfamethoxazole, amoxicillin, Augmentin, doxycycline, and fluoroquinolones. For more information on antibiotics for urinary tract infections see:
Mar 21, 2022 · Both clarithromycin and its active metabolite, 14-hydroxyclarithromycin, were found in milk. The peak clarithromycin milk level was 0.85 mg/L at 2.2 hours after the dose; the peak 14-hydroxyclarithromycin level was 0.63 mg/L at 2.8 hours after the dose. Respective trough values were 0.21 and 0.36 mg/L. The half-lives of the drug and metabolite ...
Jul 25, 2011 · Other investigations of clarithromycin have found that serum AUC 0–24 /MIC is the most accurate predictor of clarithromycin antimicrobial efficacy. 6,7 As mentioned previously, macrolides accumulate in the respiratory epithelial lining fluid where M. pneumoniae have a localized pathogenic effect. We measured clarithromycin concentrations in ...
Feb 2, 2015 · Most notably, in a prior publication, the authors compared patients taking clarithromycin with those taking azithromycin to determine the comparability of such patients for population-based studies investigating potential drug interactions. 6 The two groups were largely similar in demographic characteristics and outcomes; however, data ...
The renal clearance of clarithromycin is, however, relatively independent of the dose size and approximates the normal glomerular filtration rate. The major metabolite found in urine is 14-OH clarithromycin, which accounts for an additional 10% to 15% of the dose with either a 250 mg or a 500 mg tablet administered every 12 hours.
