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Knowledge about drug safety in pregnancy is based on research in humans and animals and on side effects that are reported by people who have taken the medication. In general, doctors advise pregnant women about taking a medication based on available research, importance of the medication to the health of the pregnant woman, and whether there ...
Dec 22, 2020 · In early pregnancy, high serum levels of human chorionic gonadotropin (hCG) have weakly thyrotrophic effects on the thyroid gland, leading to increased thyroid hormone production and negative feedback to the pituitary . Thus, in the first trimester when serum hCG levels are highest, serum TSH tends to be lower compared with nonpregnant adults.
Sep 24, 2020 · Of concern, benzodiazepine use in combination with SSRI therapy has been associated with worse adverse behavioral effects in the infants. 39 Furthermore, although rates of depression are high, only 8.6% receive adequate treatment in pregnancy, and data regarding remission rates of depression with medication during pregnancy are limited. 40 ...
Apr 23, 2015 · The authors also review adverse fetal effects associated with maternal treatment anytime in pregnancy, such as poor fetal growth, preterm birth, and neonatal abstinence syndrome. It is therefore important that health care providers discuss these recent findings with their patients and explain the potential risks and benefits of taking these ...
May 3, 2013 · There is accumulating evidence from human and animal studies that exposure to prenatal stress can affect the health, development and long-term functioning of offspring via both direct and indirect pathways ( Figure 1 ). Prenatal stress can indirectly affect infant health and development by increasing the risk of the occurrence of adverse birth ...
The side effects of pregnancy often change from month to month and, yes, they will be different for each woman. For some women, the later months of pregnancy are easier; side effects such as morning sickness and headaches gradually go away.
Changes in protein binding may also affect elimination, because only unbound drug is available to be metabolized and/or renally cleared. 18. Albumin binds acidic and neutral drugs, while a1-acid glycoprotein binds basic drugs. Concentrations of both of these proteins are decreased in pregnancy. Albumin concentrations are 70–80% lower at term ...
