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Jul 16, 2013 · Introduction. Von Willebrand disease (VWD) is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor (VWF), a multi-adhesive protein which binds platelets to exposed subendothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, FVIII, the protein deficient in hemophilia A, may be variably reduced.
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
Mar 1, 2022 · VWD may also cause problems with another clotting protein in the blood known as factor VIII. There are 3 main types of VWD: Type 1. This is the mildest and most common form. Your child has low levels of von Willebrand factor and may have low levels of factor VIII. Type 2. There are 4 subtypes of type 2 VWD. Each is treated differently.
Dec 28, 2023 · von Willebrand disease (VWD) is the most common congenital bleeding disorder with a potential incidence of 1% of the general population. The disorder is classified into three main types: type 1 and type 3 as (respectively, partial and complete) quantitative deficiency of von Willebrand factor (VWF) and type 2 (with qualitative VWF defects).
pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of preg‐ nant women with VWD to plan the most appropriate treatment at the time of par‐ turition. However, there are also instances during pregnancy (amniocentesis, vaginal
Jun 1, 2021 · In recent years, several new etiological factors for acquired hemophilia A, such as treatment with immune checkpoint inhibitors or DPP-4 inhibitors and SARS-CoV2 infection, and for acquired von Willebrand syndrome, for example, left ventricular assist devices, have been identified and also new treatment options have become available.
Causes of von Willebrand disease. Von Willebrand disease is nearly always caused by the genes you inherit from your parents. The most severe type of von Willebrand disease, called type 3, happens when a child inherits the gene from both parents. If you have type 1 or type 2, there's a 1 in 2 chance that your child will also inherit it.
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related to: von willebrand in pregnancy causes and treatment centerVisit the official VONVENDI® [von Willebrand factor (Recombinant)] website to learn more.
Find information and resources about an adult von Willebrand disease treatment.
