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説明. ジェノタイピング （ 遺伝子型 決定・遺伝子型判定）とは、ある個体の DNA 配列を DNAシークエンシング などによって識別し、他の個体のDNA配列や基準となるDNA配列と比較することによって、 遺伝子型 の違いを検出する方法である [1] [2] 。. ジェノ ...
Kompetitive allele specific PCR ( KASP) is a homogenous, fluorescence-based genotyping variant of polymerase chain reaction. It is based on allele-specific oligo extension and fluorescence resonance energy transfer for signal generation. A single-nucleotide polymorphism (SNP) occurs when a single nucleotide in a DNA sequence differs between ...
TaqMan. TaqMan probes are hydrolysis probes that are designed to increase the specificity of quantitative PCR. The method was first reported in 1991 by researcher Kary Mullis at Cetus Corporation, [1] and the technology was subsequently developed by Hoffmann-La Roche for diagnostic assays and by Applied Biosystems (now part of Thermo Fisher ...
v. t. e. Pharmacogenomics, often abbreviated "PGx," is the study of the role of the genome in drug response. Its name ( pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of a patient affects their response to drugs. [1]
Imputation (genetics) In genetics, imputation is the statistical inference of unobserved genotypes. [1] It is achieved by using known haplotypes in a population, for instance from the HapMap or the 1000 Genomes Project in humans, thereby allowing to test for association between a trait of interest (e.g. a disease) and experimentally untyped ...
Human papillomavirus infection ( HPV infection) is caused by a DNA virus from the Papillomaviridae family. [5] Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. [1] In some cases, an HPV infection persists and results in either warts or precancerous lesions. [2] These lesions, depending on the site affected ...
Genotyp, spolu s vonkajšími faktormi, ktoré ovplyvňujú DNA, určuje charakteristické vlastnosti organizmu, teda jeho fenotyp. Inak povedané, genotyp môžeme definovať ako súbor génov organizmu a fenotyp ako súbor vonkajších znakov organizmu. DNA mutácie, ktoré nie sú dedičné, ako napríklad rakovinové mutácie, nie sú ...
