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5 days ago · In line with notion, protein folding in the ER is an oxidative process that relies mainly on Endoplasmic Reticulum Oxidase 1 (ERO1α) and Protein Disulfide Isomerase (PDI). 16 Evaluation of ERO1α and PDI levels reveled that FLT3-ITD mutant cells have a higher expression of at least one of them compared to wild-type cells (Figure 2A), being ...
6 days ago · The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The accumulation of misfolded proteins in the ER leads to endoplasmic reticulum stress (ERS), resulting in activation of the unfolded protein response (UPR) that aims to restore protein homeostasis [ 11 ].
May 9, 2024 · The endoplasmic reticulum (ER) is the largest single membrane-bound intracellular compartment. It is an extensive network of closed and flattened membrane-bound structures. The enclosed compartment is called the ER lumen. ER membranes are physiologically active, interact with the cytoskeleton, and contain differentiated domains specialized for ...
5 days ago · Endoplasmic Reticulum (ER) is a three-dimensional network of intracellular membranes of eukaryotic cells. ER is a large, dynamic structure that obeys various functions in the cell including calcium storage, protein synthesis, and lipid metabolism. The endoplasmic reticulum has two major sections, which are the smooth endoplasmic reticulum and ...
May 1, 2024 · This review tries to link the association between ER with its inter- and intra-organellar interactions in vitiligo pathogenesis and focus on the function, mechanism, and clinical potential of ER with vitiligo. Abstract The endoplasmic reticulum (ER) is the main site of protein synthesis, transport, and modification. Its abnormal status has now emerged as an established cause of many ...
May 10, 2024 · Beaulant, A. et al. Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis. J. Hepatol. 77 , 710–722 (2022).
May 1, 2024 · Endoplasmic reticulum stress is closely associated with tumors, myocardial injury, and other diseases. Previous studies have demonstrated that ATF3 attenuates myocardial injury by regulating SPHK1 through the ERS pathway. 26 In colon cancer, oridonin increases cancer cell death via TP53-promoted ERS. 27 In this study, 4 differentially expressed ...
