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Sep 2, 2019 · Here, we dissect the contributions of clonal genetic diversity and transcriptional plasticity during the early and late phases of ET at single-cell resolution. Using single-cell RNA-sequencing and imaging we disentangle the transcriptional variability of plastic cells and define a rare subpopulation of pre-adapted (PA) cells which undergoes ...
Dartmouth College: NH, NH, US. 2009-06-01 to 2012-08-31 | Post Doctoral Associate (Norris Cotton Cancer Center) Employment. Show more detail. Source : luca magnani.
Professor. Breast Epigenetic Plasticity and Evolution Team Lead · How do cancer cells escape treatment? My laboratory is dedicated to finding an answer to this question so we can better predict and treat cancer patients. We focus on nongenetic mechanisms of adaptation to treatment and spend much of our time studying breast cancer. The main question in the lab is how cancer cells "learn ...
- The Institute of Cancer Research
Apr 22, 2021 · Hormone dependent breast cancer (HDBC) is the most commonly diagnosed tumor type in women. Adjuvant endocrine therapies (ET) have been the cornerstone in the clinical management of HDBC patients for over forty years. A vast proportion of HDBC patients incur long periods of clinical dormancy following ET, with tumour awakening appearing at a steady pace for up to 25 years ([Pan et al., 2017][1 ...
May 6, 2024 · Anna Magnani (born March 7, 1908, Rome, Italy—died September 26, 1973, Rome) was an Italian actress, known for her forceful portrayals of earthy, working-class women. She won the Academy Award for best actress for her performance in The Rose Tattoo (1955). Born out of wedlock, Magnani never knew her father and was deserted by her mother ...
Principal Investigator: Luca Magnani | Cancer cells exhibit altered transcriptional profiles when compared to their tissue of origin. Genetic alterations participate in promoting defective ...
Luca Magnani. Breast Epigenetic Plasticity and Evolution Lab, Institute of Cancer Research. Verified email at icr.ac.uk - Homepage. System oncology Translational science Drug resistance Epi-genomics Breast cancer. Title.
